Stathmin-2/STMN2 Antibody

Images

 
Genetic Strategies: Knockdown Validated: Stathmin-2/STMN2 Antibody [NBP1-49461] - Analysis of endogenous STMN2 in mouse dorsal root ganglia (DRG) neurons. A partial siRNA knockdown was used in the second lane. ...read more
Immunocytochemistry/ Immunofluorescence: Stathmin-2/STMN2 Antibody [NBP1-49461] - Staining of STMN2 in primary mouse dorsal root ganglia (DRG) neurons Image shows the expected staining of endogenous STMN2 in axons and ...read more
Immunohistochemistry-Frozen: Stathmin-2/STMN2 Antibody [NBP1-49461] - Neuronal deletion of Tsc2 improves axon regeneration within the first 2 d following nerve injury. SCG10 immunostaining of sciatic nerves 1 d after ...read more
Expression of Tagged Proteins: Immunocytochemistry/ Immunofluorescence: Stathmin-2/STMN2 Antibody [NBP1-49461] - Staining of STMN2 in HEK293T cells transfected with GFP or a GFP-STMN2 fusion. NBP1-49461 was used ...read more
Expression of Tagged Proteins: Western Blot: Stathmin-2/STMN2 Antibody [NBP1-49461] - Analysis of STMN2 in HEK293T cells transfected with GFP or a GFP-STMN2 fusion. NBP1-49461 was used at a dilution of 1:4000. ...read more
Immunohistochemistry-Frozen: Stathmin-2/STMN2 Antibody [NBP1-49461] - Stathmin-2/STMN2 immunoreactivity at the trigeminal root entry zone (antibody diluted 1:1000, tissue taken from a mouse with experimental autoimmune ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr, IHC-P, In vitro, In vivo, IHC-WhMt, KD
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

Stathmin-2/STMN2 Antibody Summary

Immunogen
C-terminal peptide of mouse STMN2. [Swiss-Prot P55821]
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
STMN2
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunocytochemistry/Immunofluorescence 1:4000
  • Immunohistochemistry Whole-Mount
  • Immunohistochemistry 1:1000
  • Immunohistochemistry-Frozen 1:1000
  • Immunohistochemistry-Paraffin
  • In vitro assay
  • In vivo assay
  • Knockdown Validated
  • Western Blot 1:1000-1:4000
Application Notes
Use in Immunohistochemistry Whole-Mount reported in scientific literature (PMID:35042776) In Western blot a band can be seen at ~22 kDa. Use for in vivo assays reported in the scientific literature (PMID: 22726832). Use in Immunohistochemistry-paraffin reported in scientific literature (PMID: 31182472). Use In vitro assay reported in scientific literature (PMID: 22726832). The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
22 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Reviewed Applications
Read 2 Reviews rated 4.5
using
NBP1-49461 in the following applications:

Publications
Read Publications using
NBP1-49461 in the following applications:

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID:32778834).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera
Preservative
0.05% Sodium Azide
Purity
Unpurified

Alternate Names for Stathmin-2/STMN2 Antibody

  • FLJ34868
  • FLJ50995
  • neuron-specific growth-associated protein
  • Protein SCG10
  • SCG10
  • SCG10neuronal growth-associated protein (silencer element)
  • SCGN10
  • SCGN10stathmin-2
  • Stathmin2
  • Stathmin-2
  • stathmin-like 2
  • STMN2
  • superior cervical ganglia, neural specific 10
  • Superior cervical ganglion-10 protein

Background

STMN2 (Stathmin-2 or SCG10/Scgn10) belongs to stathmin family of proteins which are known to bind tubulin for acting as a sequestering agents and for promoting microtubule disassembly. STMN2 is a membrane-associated neuronal protein expressed mainly during development and its expression correlates with neurite outgrowth. STMN2 possesses a unique N-terminal domain that is critical for membrane binding, is responsible for STMN2 localization to the Golgi complex and is important in its targeting to growth cones. STMN2 localize to perinuclear cytoplasm, axons, and growth cones of developing neurons, and exists in soluble as well as membrane-bound forms. STMN2 interacts with ITMC2, as well as MAPK8, and when phosphorylated by MAPK8, it act as regulator of microtubule stability which controls neurite length in cortical neurons. Unlike other stathmins, STMN2 acts in two ways to promote microtubule dynamics: it stabilizes microtubules at their plus end and promotes microtubule catastrophe at their minus end. In the developing brain, STMN2 negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone. Reduced STMN2 expression is associated with Down's syndrome and Alzheimer's disease.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Stathmin-2/STMN2 Antibody (NBP1-49461)(49)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

We have publications tested in 7 applications: ICC/IF, IHC, IHC-Fr, IHC-P, IHC-WhMt, In vivo, WB.


Filter By Application
ICC/IF
(12)
IHC
(18)
IHC-Fr
(3)
IHC-P
(1)
IHC-WhMt
(1)
In vivo
(2)
WB
(3)
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Human
(3)
Mouse
(25)
Rat
(7)
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Showing Publications 1 - 10 of 49. Show All 49 Publications.
Publications using NBP1-49461 Applications Species
Serger E, Luengo-Gutierrez L, Chadwick JS et al. The gut metabolite indole-3 propionate promotes nerve regeneration and repair Nature Jun 22 2022 [PMID: 35732737] (IHC, Mouse) IHC Mouse
Giovanni S, serger e, Chadwick J et al. The intermittent fasting-dependent gut microbial metabolite indole-3 propionate promotes nerve regeneration and recovery after injury Research Square Dec 16 2020 (IHC, Mouse) IHC Mouse
Zhang J, Jiang C, Liu X et al. The metabolomic profiling identifies N, N-dimethylglycine as a facilitator of dorsal root ganglia neuron axon regeneration after injury FASEB journal [PMID: 35394692]
Wang D, Zheng T, Ge X et al. Unfolded protein response-induced expression of long noncoding RNA Ngrl1 supports peripheral axon regeneration by activating the PI3K-Akt pathway Experimental neurology Feb 25 2022 [PMID: 35227685]
Niemi JP, DeFrancesco-Oranburg T, Cox A et al. The Conditioning Lesion Response in Dorsal Root Ganglion Neurons Is Inhibited in Oncomodulin Knock-Out Mice eNeuro Feb 24 2022 [PMID: 35131866] (IHC, Mouse) IHC Mouse
Lee B, Oh Y, Cho E et al. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury The Journal of biological chemistry Jan 28 2022 [PMID: 35101451]
Meng X, Qian X, Ding X et al. Eosinophils regulate intra-adipose axonal plasticity Proceedings of the National Academy of Sciences of the United States of America Jan 18 2022 [PMID: 35042776] (IHC-WhMt, Mouse) IHC-WhMt Mouse
Nogueira-Rodrigues J, Leite SC, Pinto-Costa R et al. Rewired glycosylation activity promotes scarless regeneration and functional recovery in spiny mice after complete spinal cord transection Developmental cell Dec 27 2021 [PMID: 34986324]
Yin GN, Shin TY, Ock J et al. Pericyte derived extracellular vesicles mimetic nanovesicles improves peripheral nerve regeneration in mouse models of sciatic nerve transection International journal of molecular medicine Feb 1 2022 [PMID: 34935051] (IHC-Fr, Mouse) IHC-Fr Mouse
Shen Y, Cheng Z, Chen S Et al. Dysregulated miR-29a-3p/PMP22 Modulates Schwann Cell Proliferation and Migration During Peripheral Nerve Regeneration Molecular neurobiology Nov 27 2021 [PMID: 34837628]
Show All 49 Publications.

Reviews for Stathmin-2/STMN2 Antibody (NBP1-49461) (2) 4.52

Average Rating: 4.5
(Based on 2 reviews)
We have 2 reviews tested in 2 species: Mouse, Other.

Reviews using NBP1-49461:
Filter by Applications
Immunohistochemistry-Frozen
(2)
All Applications
Filter by Species
Mouse
(1)
Other
(1)
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Images Ratings Applications Species Date Details
Immunohistochemistry-Frozen Stathmin-2/STMN2 NBP1-49461
Enlarge
5
reviewed by:
Verified Customer
Immunohistochemistry-Frozen Mouse 11/29/2018
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Summary

ApplicationImmunohistochemistry-Frozen
Sample Testedmouse trigeminal root entry zone,trigeminal root entry zone
SpeciesMouse
LotC-7
  4
reviewed by:
Alicia DeFrancesco
Immunohistochemistry-Frozen Other 08/31/2016
View

Summary

ApplicationImmunohistochemistry-Frozen
Sample Testedsciatic nerve
SpeciesOther
Lotc1

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Recent Reviews

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Verified Customer
11/29/2018
Application: Immunohistochemistry-Frozen
Species: Mouse

 
Alicia DeFrancesco
08/31/2016
Application: Immunohistochemistry-Frozen
Species: Other

Bioinformatics

Gene Symbol STMN2