STAT5b Antibody (1032E) [HRP]

• Reactivity: Hu, Mu, Rt
• Applications: WB, IP, ICC/IF, KO
• Clone: 1032E
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: HRP

STAT5b Antibody (1032E) [HRP] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Human STAT5b synthetic peptide aa 777-787
  Accession # P51692
• Specificity: Detects human, mouse, and rat STAT5b in Western blots.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: STAT5B
• Purity: Protein A or G purified from cell culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Immunoprecipitation
  • Knockout Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A or G purified from cell culture supernatant

Alternate Names for STAT5b Antibody (1032E) [HRP]

• signal transducer and activator of transcription 5B
• STAT5
• STAT5b
• transcription factor STAT5B

Background

STAT5B is encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STAT5B