SOCS-4 Antibody (517331) [Alexa Fluor® 405]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 517331
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 405

SOCS-4 Antibody (517331) [Alexa Fluor® 405] Summary

• Immunogen: E. coli-derived recombinant human SOCS-4
  Met1-Cys440
  Accession # Q8WXH5
• Specificity: Detects endogenous human and mouse SOCS-4 in Western blots.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SOCS-4 Antibody (517331) [Alexa Fluor® 405]

• CIS4
• DKFZp686J1568
• SOCS4
• SOCS-4
• SOCS7
• SOCS-7
• SSI4
• STAT4
• suppressor of cytokine signaling 4
• Suppressor of cytokine signaling 7SH2 domain containing SOCS box protein

Background

Suppressor of cytokine signaling 4 (SOCS-4) is a 51 kDa (predicted) member of the SOCS family of proteins, which are Src homology-2 (SH2)-containing proteins originally identified as negative regulators of cytokine signaling. Human SOCS-4 is 440 amino acids (aa) in length. It contains an SH2 domain (aa 289‑381) and a SOCS box domain (aa 376‑425). Human SOCS-4 shares 93% and 86% aa sequence identity with bovine and mouse SOCS-4, respectively. The biological function of SOCS-4 remains poorly understood, but it has been found to be elevated in cells following treatment with EGF, acting perhaps in a feedback loop inhibiting STAT3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.