Recombinant Human SOCS-2 GST (N-Term) Protein

12.5% SDS-PAGE Stained with Coomassie Blue.

Product Discontinued

Recombinant Human SOCS-2 GST (N-Term) Protein Summary

• Description: A recombinant protein with GST tag at N-terminal corresponding to the amino acids 1-198 of Human SOCS2
  
  

  Source: Wheat Germ (in vitro)

  Amino Acid Sequence: MTLRCLEPSGNGGEGTRSQWGTAGSAEEPSPQAARLAKALRELGQTGWYWGSMTVNEAKEKLKEAPEGTFLIRDSSHSDYLLTISVKTSAGPTNLRIEYQDGKFRLDSIICVKSKLKQFDSVVHLIDYYVQMCKDKRTGPEAPRNGTVHLYLTKPLYTSAPSLQHLCRLTINKCTGAIWGLPLPTRLKDYLEEYKFQV

• Preparation Method: in vitro wheat germ expression system
• Details of Functionality: This protein was produced in an in vitro wheat germ expression system that should preserve correct conformational folding that is necessary for biological function. While it is possible that this protein could display some level of activity, the functionality of this protein has not been explicitly measured or validated.
• Source: Wheat germ
• Protein/Peptide Type: Recombinant Protein
• Gene: SOCS2
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoaffinity Purification
  • Protein Array
  • Western Blot
• Theoretical MW: 48.6 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -80C. Avoid freeze-thaw cycles.
• Buffer: 50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
• Preservative: No Preservative
• Purity: >80% by SDS-PAGE and Coomassie blue staining

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Recombinant Human SOCS-2 GST (N-Term) Protein

• CIS2
• CIS2CIS-2
• Cish2
• Cytokine-inducible SH2 protein 2
• SOCS2
• SOCS-2
• SOCS-2STAT-induced STAT inhibitor 2
• SSI2
• SSI-2STAT induced STAT inhibitor-2
• SSI2STAT-induced STAT inhibitor-2
• STATI2
• STATI2suppressor of cytokine signaling-2
• suppressor of cytokine signaling 2

Background

This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

Publications for SOCS-2 Recombinant Protein (H00008835-P01)(2)

Publications using H00008835-P01

• TB Lear, AC McKelvey, JW Evankovich, S Rajbhandar, TA Coon, SR Dunn, JD Londino, BJ McVerry, Y Zhang, E Valenzi, CL Burton, R Gordon, S Gingras, KC Lockwood, MJ Jurczak, R Lafyatis, MJ Shlomchik, Y Liu, BB Chen KIAA0317 regulates pulmonary inflammation through SOCS2 degradation JCI Insight, 2019-10-03;4(19):. 2019-10-03 [PMID: 31578312]
• Sen B, Peng SH, Woods DM et al. STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma. Clin Cancer Res. 2011-11-16 [PMID: 22090359]

Bioinformatics

• Gene Symbol: SOCS2