SOCS-1 Antibody

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Western Blot: SOCS-1 Antibody [NB100-56637] - Analysis of SOCS-1 using NB100-56637 at 1:1000 dilution against 15 ug/lane of Ramos (A) and Raw (B) cell lysate.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.

Order Details

SOCS-1 Antibody Summary

Immunogen
A synthetic peptide corresponding to amino acids 54-68 (HFRTFRSHADYRRIT) of human SOCS1 was used as immunogen (NP_003736.1)
Specificity
This should cross-react with rat SOCS1, based on amino acid sequence.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SOCS1
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
23.55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
NB100-56637 in the following applications:

  • WB
    2 publications

Reactivity Notes

Cross reacts with Human and Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Whole antisera with PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.
Purity
Unpurified

Alternate Names for SOCS-1 Antibody

  • CIS1
  • Cish1
  • JAB
  • JABTec-interacting protein 3
  • JAK binding protein
  • JAK-binding protein
  • SOCS1
  • SOCS-1
  • SOCS-1CIS1
  • SSI-1
  • SSI-1CISH1
  • SSI1cytokine-inducible SH2 protein 1
  • STAT induced SH3 protein 1
  • STAT-induced STAT inhibitor 1
  • suppressor of cytokine signaling 1
  • TIP3
  • TIP-3
  • TIP3Cish1

Background

The suppressor of cytokine signaling (SOCS) family of proteins (SOCS1-SOCS7 and CIS) inhibit cytokine production by a classical negative feedback mechanism. These proteins are upregulated in response to cytokine stimulation followed by inhibition of cytokine-inducing signal pathway. Role of each members of the family has been determined by gene knockout experiments (1). SOCS1 also known as JAB and (STAT)-induced STAT inhibitor 1 (SSI-1) is an SH2-domain-containing protein that is induced by and negatively regulates signaling by a number of cytokines including interleukin-4 (IL-4), IL-6, interferon (IFN)-gamma, prolactin, growth hormone, and erythropoietin (1). SOCS1/JAB is rapidly induced by LPS and negatively regulates LPS signaling (2). SOCS1 (-/-) mice are very sensitive to LPS. These mice die prematurely, probably due to uncontrolled IFN-g signaling (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SOCS-1 Antibody (NB100-56637)(4)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SOCS1
Entrez
Uniprot