SOCS-2 Research Products: Novus Biologicals

SOCS-2 Antibodies (5)

SOCS-2 Lysate (1)

SOCS-2 Proteins (2)

Antibodies

SOCS-2 Antibody (JG36-86)

NBP2-75671

Immunocytochemistry/Immunofluorescence SOCS-2 Antibody (JG36-86)

Species: Hu
Applications: WB, ICC/IF, IP
Host: Rabbit Monoclonal

SOCS-2 Antibody [Unconjugated ...

AF4979

Species: Hu
Applications: WB
Host: Goat Polyclonal

Formulation	Catalog #	Availability	Price
Carrier Free	AF4979-SP

SOCS-2 Antibody (517206) [Unc ...

MAB4979

Species: Hu
Applications: WB
Host: Mouse Monoclonal

Formulation	Catalog #	Availability	Price
Carrier Free	MAB4979-SP

We have 5 SOCS-2 Antibodies

Lysates

SOCS-2 Overexpression Lysate

NBL1-16326

Species: Hu
Applications: WB

We have 1 SOCS-2 Lysate

Proteins

Recombinant Human SOCS-2 GST ...

H00008835-P01

(1 Publication)

Species: Hu
Applications: WB, ELISA, PA, AP

Recombinant Human SOCS-2 GST ...

H00008835-Q01

Species: Hu
Applications: WB, ELISA, PA, PAGE, AP

We have 2 SOCS-2 Proteins

Description

Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules TermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previouslyunrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCSfamily appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

Bioinformatics

Entrez	8835 Human 216233 Mouse 84607 Rat
Uniprot	O14508 Human NP_003868.1 Human AAH10399 Human NM_003877 Human
Product By Gene ID	8835
Alternate Names	Cish2 STATI2suppressor of cytokine signaling-2 SSI2STAT-induced STAT inhibitor-2 SSI-2STAT induced STAT inhibitor-2 SOCS-2STAT-induced STAT inhibitor 2 CIS2CIS-2 Cytokine-inducible SH2 protein 2 suppressor of cytokine signaling 2