SOCS-2 Products

Description

Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules TermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previouslyunrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCSfamily appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

Bioinformatics

Entrez	8835 Human 216233 Mouse 84607 Rat
Uniprot	NM_003877 Human O14508 Human NP_003868.1 Human AAH10399 Human
Product By Gene ID	8835
Alternate Names	Cish2 STATI2suppressor of cytokine signaling-2 SSI2STAT-induced STAT inhibitor-2 SSI-2STAT induced STAT inhibitor-2 SOCS-2STAT-induced STAT inhibitor 2 CIS2CIS-2 Cytokine-inducible SH2 protein 2 suppressor of cytokine signaling 2

Diseases related to SOCS-2

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Janiceps
Malignant Neoplasms
Neoplasms
Inflammation
Leukemia
Carcinoma
Malignant Neoplasm Of Breast
Diabetes Mellitus
Mammary Neoplasms
Nervousness
Myeloid Leukemia
Cell Transformation, Neoplastic
Liver Carcinoma
Lymphoma
Insulin Resistance
Obesity
Kidney Diseases
Dwarfism
Hypertrophy
Hyperplasia

Pathways for SOCS-2

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Pathogenesis
Cell Proliferation
Cell Differentiation
Secretion
Immune Response
Methylation
Cell Activation
Cell Cycle
Lactation
Regeneration
T Cell Activation
Cell Growth
Aging
Cytokine Production
Regulation Of Growth
Neurogenesis
Cell Death
Gland Development
T Cell Differentiation
Insulin Secretion

Research Areas for SOCS-2

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Signal Transduction

PTMs for SOCS-2

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Phosphorylation
Methylation
Ubiquitination
Dephosphorylation
Demethylation
Reduction
Cleavage
Acetylation

Bioinformatics Tool for SOCS-2

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