SOCS-2 Products

Antibodies
SOCS-2 Antibody (517206)
SOCS-2 Antibody (517206)
MAB4979
Species: Hu
Applications: WB
Host: Mouse Monoclonal
SOCS-2 Antibody
SOCS-2 Antibody
AF4979
Species: Hu
Applications: WB
Host: Goat Polyclonal
SOCS-2 Antibody
SOCS-2 Antibody
NB600-1338
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Rabbit Polyclonal
Lysates
SOCS-2 Overexpression Lysate ...
SOCS-2 Overexpression Lysate (Native)
NBL1-16326
Applications: WB
Proteins
SOCS-2 Recombinant Protein
SOCS-2 Recombinant Protein
H00008835-P01
Species: Hu
Applications: WB, ELISA, PA
SOCS-2 Partial Recombinant Pr ...
SOCS-2 Partial Recombinant Protein
H00008835-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
SOCS-2 RNAi
SOCS-2 RNAi
H00008835-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Accumulating evidence demonstrates that cytokine receptorsignaling is negatively regulated by a family of Srchomology 2 domain-containing adaptor molecules TermedSOCS (Suppressor of Cytokine Signaling). To date, there are eight members of SOCS family have beenrecognized, they are SOCS 1, 2, 3, 4, 5, 6, 7 and CIS. Structurally the SOCS proteins are composed of an Nterminalregion of variable length and amino acidcomposition, a central SH2 domain, and a previouslyunrecognized C-terminal motif that we have called the SOCS box. The SOCS proteins appear to form part of aclassical negative feed back loop that regulates cytokinesignal transduction via a STAT induced transcriptionalmechanism. Transcription of each of the SOCS genesoccurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCSfamily appear to inhibit signaling in different ways. SOCS 2, not like SOCS 1 and SOCS 3, regulates postnatalgrowth, likely through its ability to influence the GH / IGF 1axis, although they might have overlapping actions.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 8835
Alternate Names
  • Cish2
  • STATI2suppressor of cytokine signaling-2
  • SSI2STAT-induced STAT inhibitor-2
  • SSI-2STAT induced STAT inhibitor-2
  • SOCS-2STAT-induced STAT inhibitor 2
  • CIS2CIS-2
  • Cytokine-inducible SH2 protein 2
  • suppressor of cytokine signaling 2

Research Areas for SOCS-2

Find related products by research area and learn more about each of the different research areas below.

Signal Transduction

Bioinformatics Tool for SOCS-2

Discover related pathways, diseases and genes to SOCS-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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