SOCS-1 Antibody - BSA Free

Western Blot: SOCS-1 Antibody [NBP1-58943] - Lanes: 1. Mouse WT brain extract (80ug) 2. Rat brain extract (80ug) Primary Antibody Dilution: 2ug/ml Secondary Antibody: IRDye 800CW goat anti-rabbit from Li-COR Bioscience Secondary Antibody Dilution: 1: 20,000 Gene Name: SOCS1

Immunohistochemistry: SOCS-1 Antibody [NBP1-58943] - Paraffin Embedded Tissue: Human Kidney Cellular Data: Epithelial cells of renal tubule Antibody Concentration: 4.0 - 8.0 ug/ml Magnification: 400X

Western Blot: SOCS-1 Antibody [NBP1-58943] - Jurkat Lysate (20 ug). Antibody at 1.25 ug/mL.

Western Blot: SOCS-1 Antibody [NBP1-58943] - Jurkat cell lysate, concentration 0.2-1 ug/ml.

Western Blot: SOCS-1 Antibody [NBP1-58943] - Mouse WT brain and Rat brain, antibody at 2 ug/mL.

• Reactivity: Hu, Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

SOCS-1 Antibody - BSA Free Summary

• Description: The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.
• Immunogen: This SOCS-1 antibody is made to synthetic peptides corresponding to SOCS1 (suppressor of cytokine signaling 1). The peptide sequence was selected from the N terminal of SOCS1. Peptide sequence RRPEPSSSSSSSPAAPARPRPCPAVPAPAPGDTHFRTFRSHADYRRITRA. The peptide sequence for this immunogen was taken from within the described region.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: SOCS1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10 - 1:500
  • Immunohistochemistry-Paraffin 1:10 - 1:500
  • Western Blot 1.0 ug/ml

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS, 2% Sucrose
• Preservative: 0.09% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for SOCS-1 Antibody - BSA Free

• CIS1
• Cish1
• JAB
• JABTec-interacting protein 3
• JAK binding protein
• JAK-binding protein
• SOCS1
• SOCS-1
• SOCS-1CIS1
• SSI-1
• SSI-1CISH1
• SSI1cytokine-inducible SH2 protein 1
• STAT induced SH3 protein 1
• STAT-induced STAT inhibitor 1
• suppressor of cytokine signaling 1
• TIP3
• TIP-3
• TIP3Cish1

Background

SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. SOCS1 functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of its gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SOCS1
• Uniprot:
  • O15524(Human)