SNF1LK2/SIK2 Antibody [Alexa Fluor® 532]

• Reactivity: Hu
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 532

SNF1LK2/SIK2 Antibody [Alexa Fluor® 532] Summary

• Immunogen: E. coli-derived recombinant human SNF1LK2
  Ala663-Leu818
  Accession # Q9H0K1
• Specificity: Detects human SNF1LK2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for SNF1LK2/SIK2 Antibody [Alexa Fluor® 532]

• DKFZp434K1115
• EC 2.7.11
• EC 2.7.11.1
• KIAA0781SIK-2
• LOH11CR1I
• QIK
• QIKSNF1LK2
• Qin-induced kinase
• salt-inducible kinase 2
• Salt-inducible protein kinase 2
• salt-inducible serine/threonine kinase 2
• serine/threonine-protein kinase SIK2
• Serine/threonine-protein kinase SNF1-like kinase 2
• SIK2
• SNF1-like kinase 2
• SNF1LK2

Background

SNF1LK2 (Sucrose non-fermenting 1 like kinase 2) also known as SIK2 (Salt-inducible kinase 2) is a cytoplasmic 125 kDa member of the CAMK Ser/Thr protein kinase family, AMPK subfamily of enzymes. It is expressed in preadipocytes/adipocytes, with levels strongly induced during early differentiation. SNF1LK2 regulates the early phase of insulin signaling by phosphorylating IRS-1 on Ser794. Human SNF1LK2 is 926 amino acids (aa) in length and contains a protein kinase domain (aa 20‑271) with an ATP binding site (Lys49) and a catalytic loop (aa 140‑149), followed by a phosphorylation activation site at Thr175, a UBA (ubiquitin-associated) domain (aa 295‑335) and another PKA-dependent phosphorylation site at Ser587.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.