SMC5 Antibody

Product Discontinued

SMC5 Antibody Summary

• Immunogen: Peptide with sequence C-TSKHLEHKDNELRQ corresponding to internal region according to NP_055925.2.
• Epitope: Internal region
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SMC5
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
• Application Notes: WB: Preliminary experiments in human kidney and liver lysates and in lysates of HeLa gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for SMC5 Antibody

• hSMC5
• KIAA0594SMC5 structural maintenance of chromosomes 5-like 1 (yeast)
• SMC protein 5
• SMC-5
• SMC5L1SMC5 structural maintenance of chromosomes 5-like 1
• structural maintenance of chromosomes 5
• structural maintenance of chromosomes protein 5

Background

SMC (Structural maintenance of chromosomes) proteins are members of multisubunit complexes that play a critical role in chromosome organization, segregation, gene regulation, and DNA repair. Two of these complexes, cohesin and condensin consist of a core complex of an SMC1 and SMC3 heterodimer or an SMC2 and SMC4 heterodimer, respectively. A third complex includes a heterodimer of SMC5 and SMC6 whose function is not fully understood but is proposed to be related to DNA repair.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SMC5 Antibody (NBP1-46115)(1)

Publication using NBP1-46115

• Pebernard S, Perry JJ, Tainer JA, Boddy MN. Nse1 RING-like domain supports functions of the Smc5-Smc6 holocomplex in genome stability. Mol Biol Cell 2008-10-01 [PMID: 18667531]

Bioinformatics

• Gene Symbol: SMC5
• Entrez:
  • 23137(Human)
  • 226026(Mouse)
  • 293967(Rat)
• Uniprot:
  • NP_055925.2(Human)