SLC7A5/LAT1 Antibody (BU53) [PerCP]

• Reactivity: Hu
• Applications: Flow, IHC, CyTOF-ready
• Clone: BU53
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP

SLC7A5/LAT1 Antibody (BU53) [PerCP] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Plasma cell line 8226
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: SLC7A5
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow (Cell Surface)
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-50465. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for SLC7A5/LAT1 Antibody (BU53) [PerCP]

• 4F2 LC
• 4F2LC
• CD98
• CD98lc
• D16S469EL-type amino acid transporter 1
• E16
• Integral membrane protein E16
• large neutral amino acids transporter 1
• large neutral amino acids transporter small subunit 1
• LAT1
• LAT1hLAT1
• MPE16
• MPE16CD98 light chain
• SLC7A5
• sodium-independent neutral amino acid transporter LAT1,4F2LC
• solute carrier family 7 (cationic amino acid transporter, y+ system), member 5,4F2 light chain
• Solute carrier family 7 member 5
• TA1
• y+ system cationic amino acid transporter

Background

Mammalian cells have several amino acid transport systems. These systems have been defined by both activity and specific genes. L-type amino acid transporter 1 (LAT1) is a 12 membrane-spanning protein. LAT1 is a Na + -independent neutral amino acid transporter agency and essential for the transporter of large neutral amino acid such as Leucine, Isoleucine, and Valine through the plasma membrane. LAT1 has been proposed to be one of the major nutrient transport systems at the blood-brain barrier. Drugs such as L Dopa are transported by LAT1. LAT1 is thought to be up-regulated to support the high protein synthesis for cell growth in some tumor cell lines.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SLC7A5/LAT1 Antibody (NBP2-50465PCP)(2)

Publications using NBP2-50465PCP

• Zhao Y, Pu C, Liu K et al. Targeting LAT1 with JPH203 to reduce TNBC proliferation and reshape suppressive immune microenvironment by blocking essential amino acid uptake. Amino acids 2025-05-16 [PMID: 40379991]
• Liu YH, Li YL, Shen HT et al. L-Type Amino Acid Transporter 1 Regulates Cancer Stemness and the Expression of Programmed Cell Death 1 Ligand 1 in Lung Cancer Cells Int J Mol Sci 2021-10-11 [PMID: 34681614] (FLOW, Human)
  
  Details:
  Citation using the PerCP format of this antibody.

Bioinformatics

• Gene Symbol: SLC7A5