SKAP55 Antibody [DyLight 650]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: DyLight 650

SKAP55 Antibody [DyLight 650] Summary

• Immunogen: E. coli-derived recombinant human SKAP55
  Met1-Arg358
  Accession # NP_001068567
• Specificity: Detects human SKAP55 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: SKAP1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for SKAP55 Antibody [DyLight 650]

• SCAP1
• SCAP1pp55
• SKAP1
• SKAP55
• SKAP55SKAP-55
• src family associated phosphoprotein 1
• Src family-associated phosphoprotein 1
• src kinase associated phosphoprotein 1
• src kinase-associated phosphoprotein 1
• Src kinase-associated phosphoprotein of 55 kDa

Background

Src kinase-associated phosphoprotein of 55 kDa (SKAP55) is expressed as a constitutively tyrosine phosphorylated 55-kD adapter protein that positively regulates TCR signaling. SKAP55 has also been shown to enhance adhesion to fibronectin and ICAM1, colocalize with F-actin at the T cell-antigen-presenting cell synapse and promotes the clustering of LFA1 and TCR ligation. TCR engagement induces the translocation of SKAP55 to lipid rafts, where the interactions with Fyn take place. CD45 also plays a very important role in SKAP55/TCR-mediated signaling. SKAP55 involvement in the TCR signaling pathway is the subject of current research in murine as well as human models.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SKAP1