SKAP55 Products

Description

Src kinase-associated phosphoprotein of 55 kDa (SKAP55) is expressed as a constitutively tyrosine phosphorylated 55-kD adapter protein that positively regulates TCR signaling. SKAP55 has also been shown to enhance adhesion to fibronectin and ICAM1, colocalize with F-actin at the T cell-antigen-presenting cell synapse and promotes the clustering of LFA1 and TCR ligation. TCR engagement induces the translocation of SKAP55 to lipid rafts, where the interactions with Fyn take place. CD45 also plays a very important role in SKAP55/TCR-mediated signaling. SKAP55 involvement in the TCR signaling pathway is the subject of current research in murine as well as human models.

Bioinformatics

Entrez	8631 Human
Uniprot	AAH47870 Human NM_001075099 Human NM_003726 Human NP_003717 Human Q86WV1 Human
Product By Gene ID	8631
Alternate Names	SCAP1pp55 SKAP55SKAP-55 src family associated phosphoprotein 1 Src family-associated phosphoprotein 1 src kinase associated phosphoprotein 1 src kinase-associated phosphoprotein 1 Src kinase-associated phosphoprotein of 55 kDa