Siglec-11 Antibody

Images

 
Western Blot: Siglec-11 Antibody [NBP1-77025] - HepG2 cell lysate with Siglec11 antibody at 1 ug/mL.
Immunocytochemistry/ Immunofluorescence: Siglec-11 Antibody [NBP1-77025] - Immunofluorescence of SIGLEC11 in human liver tissue with SIGLEC11 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: Siglec-11 Antibody [NBP1-77025] - Human liver tissue with Siglec11 antibody at 5 ug/ml.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Siglec-11 Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide from near the carboxy terminus of human Siglec11. The immunogen is located within the last 50 amino acids of Siglec11.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
SIGLEC11
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 5 ug/mL
  • Immunohistochemistry-Paraffin 1:10-1:500
Control Peptide
Siglec-11 Peptide (NBP1-77025PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Siglec-11 Antibody

  • sialic acid binding Ig-like lectin 11
  • sialic acid-binding Ig-like lectin 11
  • Sialic acid-binding lectin 11
  • Siglec11
  • Siglec-11

Background

Siglecs are sialic acid-binding lectins of the immunoglobulin superfamily that are mainly expressed in cells of the hematopoietic system. Siglec11 is unlike other siglecs in that it binds specifically to alpha2-8-linked sialic acids and is not found in peripheral blood leukocytes but instead on macrophages of various tissues. Siglec11 is highly homologous to Siglec10 over their extracellular domain but not over their cytoplasmic domain, suggesting that Siglec11 arose through gene duplication followed by a recombination event involving another ancestral siglec gene. Following treatment of Siglec11-transfected cells with pervanadate, Siglec11 becomes tyrosine-phosphorylated and strongly associates with SHP-1 and SHP-2. At least five isoforms of Siglec11 are known to exist. Siglec11 antibody will not cross-react with Siglec10. Despite its predicted size, Siglec11 migrates at a higher than expected molecular weight in SDS-PAGE.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol SIGLEC11
Entrez
Uniprot