Siglec-1/CD169 Antibody (3D6.112 (recombinant version)) - Chimeric - Azide and BSA Free

• Reactivity: Mu
• Applications: WB, IHC
• Clone: 3D6.112 (recombinant version)
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: Azide and BSA Free
• Concentration: 1 mg/ml

Siglec-1/CD169 Antibody (3D6.112 (recombinant version)) - Chimeric - Azide and BSA Free Summary

• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: Spleen cells from AO rats immunised with thioglycollate-elicted murine peritoneal macrophages (TPM) that had been cutured in mouse serum to induce sheep erythrocyte receptor (SER).
• Isotype: IgG Kappa
• Clonality: Monoclonal
• Host: Rabbit
• Gene: SIGLEC1
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot
• Application Notes: This chimeric rabbit antibody was made using the variable domain sequences of the original rat IgG2a format, for improved compatibility with existing reagents, assays and techniques.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Proclin 300
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Siglec-1/CD169 Antibody (3D6.112 (recombinant version)) - Chimeric - Azide and BSA Free

• CD169
• FLJ00051
• sialic acid binding Ig-like lectin 1, sialoadhesin
• sialoadhesin
• Siglec1
• Siglec-1

Background

The siglecs are a family of membrane bound lectins (of the immunoglobulin superfamily) that bind sialic acid and mediate cell-cell interactions. Family members include sialoadhesin, CD22 and CD33. Sialoadhesin is a macrophage-specific cell adhesion molecule that is expressed on activated macrophages in chronic inflammation and in tumours.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Siglec-1/CD169 Antibody (NBP3-08989)(1)

Publication using NBP3-08989

• Willis KA, Silverberg M, Martin I et al. The fungal intestinal microbiota predict the development of bronchopulmonary dysplasia in very low birthweight newborns medRxiv : the preprint server for health sciences 2023-06-22 [PMID: 37398134] (Mouse)

Bioinformatics

• Gene Symbol: SIGLEC1