Serpin D1/Heparin Cofactor II Antibody [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor Plus 680

Serpin D1/Heparin Cofactor II Antibody [Alexa Fluor™ Plus 680] Summary

• Specificity: Detects human Serpin D1/Heparin Cofactor II in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse Serpin D1 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Serpin D1/Heparin Cofactor II Antibody [Alexa Fluor™ Plus 680]

• HC2
• HC2LS2
• HCF2
• HCF2clade D (heparin cofactor), member 1
• HC-II
• Heparin Cofactor II
• HLS2HCII
• leuserpin 2
• LS2
• Protease inhibitor leuserpin-2
• Serpin D1
• serpin peptidase inhibitor, clade D (heparin cofactor), member 1

Background

Serpin D1, also known as Heparin Cofactor II, is a member of the Serpin superfamily of the serine protease inhibitors (1). Similar to Serpins A5 and C1, it inhibits thrombin and this activity is enhanced by heparin. Interestingly, a C-terminal His-tagged recombinant Serpin D1 had enhanced heparin effect, which was maintained in a plasma-based thrombin inhibition assay (2). Congenital Serpin D1 deficiency is a potential risk factor for thrombosis (3). The full-length human cDNA was expressed and the purified protein corresponded to the secreted form with anti-thrombin activity.

1. Silverman, G.A. et al. (2001) J. Biol. Chem. 276:33293.
2. Bauman, S.J. et al. (1999) J. Biol. Chem. 274:34556.
3. Tollefsen, D.M. (2002) Arch. Pathol. Lab. Med. 126:1394.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.