| Reactivity | HuSpecies Glossary |
| Applications | WB, IP, B/N |
| Clonality | Polyclonal |
| Host | Goat |
| Conjugate | Alexa Fluor 405 |
| Immunogen | S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Serpin D1/Heparin Cofactor II Gly20-Ser499 Accession # P05546 |
| Specificity | Detects human Serpin D1/Heparin Cofactor II in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 50% cross-reactivity with recombinant mouse Serpin D1 is observed. |
| Isotype | IgG |
| Clonality | Polyclonal |
| Host | Goat |
| Purity Statement | Antigen Affinity-purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied |
| Buffer | Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide |
Serpin D1, also known as Heparin Cofactor II, is a member of the Serpin superfamily of the serine protease inhibitors (1). Similar to Serpins A5 and C1, it inhibits thrombin and this activity is enhanced by heparin. Interestingly, a C-terminal His-tagged recombinant Serpin D1 had enhanced heparin effect, which was maintained in a plasma-based thrombin inhibition assay (2). Congenital Serpin D1 deficiency is a potential risk factor for thrombosis (3). The full-length human cDNA was expressed and the purified protein corresponded to the secreted form with anti-thrombin activity.
![Serpin D1/Heparin Cofactor II Antibody [Alexa Fluor® 405]](/sites/all/modules/enterprise-tech/et_datasheets/images/novus_guarantee.png "Serpin D1/Heparin Cofactor II Antibody [Alexa Fluor® 405]")
Secondary Antibodies |
Isotype Controls |
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