Serpin A6/Cortisol Binding Globulin Antibody (037) [CoraFluor™ 1]

• Reactivity: Hu
• Applications: ELISA
• Clone: 037
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: CoraFluor 1

Serpin A6/Cortisol Binding Globulin Antibody (037) [CoraFluor™ 1] Summary

• Description: CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.
• Additional Information: Recombinant Monoclonal Antibody
• Immunogen: This antibody was obtained from a rabbit immunized with purified, recombinant Human Serpin A6/Cortisol Binding Globulin (Accession#: NP_001747.2; Met 1-Val 405).
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Gene: SERPINA6
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark. Do not freeze.
• Buffer: PBS
• Preservative: No Preservative
• Purity: Protein A purified

Notes

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

Alternate Names for Serpin A6/Cortisol Binding Globulin Antibody (037) [CoraFluor™ 1]

• antitrypsin), member 6
• CBG
• CBGcorticosteroid-binding globulin
• corticosteroid binding globulin
• member 6
• serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase
• Serpin A6
• serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin)
• transcortin

Background

Corticol binding globulin (CBG or transcotin) binds with high affinity to cortisol in plasma. Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: SERPINA6