Serotonin N-acetyltransferase Antibody [DyLight 488]

Product Discontinued

Serotonin N-acetyltransferase Antibody [DyLight 488] Summary

• Immunogen: Human Serotonin N-acetyltransferase [UniProt# Q16613]
• Specificity: This is specific for primate AANAT (3,4).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AANAT
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: This Serotonin N-acetyltransferase antibody is useful for Immunocytochemistry/Immunofluorescence and Western Blot. By Western blot, this antibody recognizes a band at 23 kDa.
  
  The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human and rhesus macaque. The antibody does not recognize rat, bovine, chicken or zebrafish.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for Serotonin N-acetyltransferase Antibody [DyLight 488]

• AA-NAT
• aralkylamine N-acetyltransferaseEC 2.3.1.87
• arylalkylamine N-acetyltransferase
• Serotonin acetylase
• SNATserotonin N-acetyltransferase

Background

Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme is melatonin synthesis. Hormonal melatonin has been implicated in sleep and circadian clock function, and acts as"the hormone of the night." Large changes in the abundance of AANAT are believed to be responsible for the large day/night rhythms in melatonin synthesis in the pineal gland and retina (1,2). Most research shows that AANAT activity is regulated by controlling the steady-state levels of the protein. Recent research, however, suggests that another mechanism may also play a role in controlling melatonin production without altering AANAT protein and activity. This mechanism may explain the sudden physiological increase in circulating melatonin observed at the onset of the dark period in humans (3).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: AANAT