Melatonin R1A/MT1/MTNR1A Antibody

Western Blot: Melatonin R1A/MT1/MTNR1A Antibody [NBP1-28912] - Staining of Rat Retina lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour.Detected by chemiluminescence.

• Reactivity: Rt, Hu, Mu, Bv, Ca
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Melatonin R1A/MT1/MTNR1A Antibody Summary

• Immunogen: Peptide with sequence C-SLKYDKLYSSKNS corresponding to internal region according to NP_005949.1.
• Predicted Species: Human (100%), Mouse (100%), Bovine (100%), Canine (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: MTNR1A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:6000
  • Western Blot 0.3 - 1 ug/ml
• Application Notes: WB: Approx. 45 kDa band observed in KELLY lysate (calculated MW of 39.4 kDa band according to NP_005949.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Melatonin R1A/MT1/MTNR1A Antibody

• Mel1a receptor
• Mel-1A-R
• Melatonin R1A
• melatonin receptor 1A
• melatonin receptor type 1A
• MelatoninR1A
• MT1
• MTNR1A

Background

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Melatonin R1A/MT1/MTNR1A Antibody (NBP1-28912)(5)

Publications using NBP1-28912

• Shearn, CT;Anderson, AL;Devereaux, MW;El Kasmi, KC;Orlicky, DJ;Sokol, RJ; Expression of circadian regulatory genes is dysregulated by increased cytokine production in mice subjected to concomitant intestinal injury and parenteral nutrition PloS one 2023-08-30 [PMID: 37647292]
• Kim NN, Choi YU, Park HS, Choi CY. Kisspeptin regulates the somatic growth-related factors of the cinnamon clownfish Amphiprion melanopus. Comp Biochem Physiol A Mol Integr Physiol. 2014-09-15 [PMID: 25220187]
• Rawashdeh O, de Borsetti NH, Roman G, Cahill GM. Melatonin suppresses nighttime memory formation in zebrafish. Science 2007-11-01 [PMID: 18006748]
• Ah Song J, Yong Choi J, Na Kim N. Effect of LED light spectra on exogenous prolactin-regulated circadian rhythm in goldfish, Carassius auratus. Biological Rhythm Research. 2014-10-01
• Esposito T, Magliocca S, Formicola D, Gianfrancesco F. piR_015520 Belongs to Piwi-Associated RNAs Regulates Expression of the Human Melatonin Receptor 1A Gene. PLoS ONE. 2011-01-01 [PMID: 21818375]

FAQs for Melatonin R1A/MT1/MTNR1A Antibody (NBP1-28912). (Showing 1 - 3 of 3 FAQs).

1. I saw that you have the antibodies for the both receptors of melatonin but not listed with FACS application. I need more information about what is better for my assay.
   • At this time, none of our melatonin receptor antibodies have been tested and validated in Flow. Should you choose to purchase and test one of them, you would qualify for the Innovator's Rewards program. You should take a look at each individual antibody, the clonality, conjugates, immunogen region and all relevant data in order to decide which product would be most suitable for your needs.
2. Do you have MTNR1A polyclonal antibody ?
   • We have five antibodies to MTNR1A that are polyclonal
3. Do you have MTNR1A polyclonal antibody ?
   • Here are our MTNR1A antibodies that are polyclonal

Bioinformatics

• Gene Symbol: MTNR1A
• Entrez:
  • 4543(Human)
• Uniprot:
  • P48039(Human)