SENP6 Antibody

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Western Blot: SENP6 Antibody [NBP1-00238] - Analysis of SENP6 in HeLa cell nuclear lysate (35ug protein in RIPA buffer) using NBP1-00238 at 0.5ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SENP6 Antibody Summary

Immunogen
Peptide with sequence C-KPKYEPNPHYHEN corresponding to internal region according to NP_056386.2.
Specificity
This antibody is expected to recognise both reported isoforms (NP_001093879.1; NP_056386.2).
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
SENP6
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 1.5 ug/ml
  • Peptide ELISA Detection limit 1:32000
Application Notes
WB: Approx. 150 kDa band observed in HeLa nuclear lysates (calculated MW of 125 kDa band according to NP_001093879.1 and of 126 kDa band according to NP_056386.2).
Publications
Read Publication using NBP1-00238.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SENP6 Antibody

  • EC 3.4.22.-
  • KIAA0797FLJ11887
  • Sentrin/SUMO-specific protease SENP6
  • sentrin-specific protease 6
  • SSP1KIAA0389
  • SUMO1/sentrin specific peptidase 6,2810017C20Rik
  • SUMO1/sentrin specific protease 6
  • SUMO-1-specific protease 1
  • SUSP1FLJ11355

Background

Ubiquitin-like molecules (UBLs), such as SUMO1 (UBL1; MIM 601912), are structurally related to ubiquitin (MIM 191339) and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 (MIM 602362) to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha (NFKBIA; MIM 164008) from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins (Kim et al., 2000 [PubMed 10799485]).[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SENP6 Antibody (NBP1-00238)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol SENP6
Entrez
Uniprot