ELOVL1 Antibody

Immunohistochemistry-Paraffin: ELOVL1 Antibody [NBP3-12302] - Mouse retina. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

Immunohistochemistry-Paraffin: ELOVL1 Antibody [NBP3-12302] - Human skin. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

Immunohistochemistry-Paraffin: ELOVL1 Antibody [NBP3-12302] - Baboon kidney. 1:100 dilution in IHC blocking buffer. DAB (brown) staining and Hematoxylin QS (blue) counterstain. 40X magnification.

• Reactivity: Hu, Mu, Pm
• Applications: WB, ELISA, IHC, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

ELOVL1 Antibody Summary

• Description: Novus Biologicals Rabbit ELOVL1 Antibody (NBP3-12302) is a polyclonal antibody validated for use in IHC, WB, ELISA and IP. Anti-ELOVL1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic peptide taken within amino acid region 148-198 on human Elongation of very long chain fatty acids protein 1.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ELOVL1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:10000
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Paraffin 1:100
  • Immunoprecipitation 1:200
  • Western Blot 1:500

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for ELOVL1 Antibody

• EC 2.3.1.n8
• elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 1
• elongation of very long chain fatty acids protein 1
• SSC1
• Ssc1,3-keto acyl-CoA synthase ELOVL1

Background

Elongation of very long chain fatty acid-like (ELOVL) proteins 1-6 are members of the ELO family of proteins, which play an important role in tissue-specific biosynthesis of very long chain fatty acids and sphingolipids. The ELOVL proteins act as catalysts in fatty acid elongation reduction and localize to the endoplasmic reticulum (ER). Elongation of very long chain fatty acids protein 1 (ELOVL1), also referred to as Ssc1, is the human homolog of the yeast ELO3 protein. It is expressed in a variety of tissues and at especially high levels in stomach, skin, intestine, kidney and lung. ELOVL1 participates in the elongation of very long chain saturated and monounsaturated fatty acids of up to 26 carbons and may be required for the development of a barrier in epithelial cells and skin. ELOVL1 is also important for the formation of Myelin in the central nervous system. Impaired ELOVL1 activity may be associated with disorders of sphingolipid metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ELOVL1 Antibody (NBP3-12302)(1)

Publication using NBP3-12302

• Enrica Flori, Alessia Cavallo, Sarah Mosca, Daniela Kovacs, Carlo Cota, Marco Zaccarini, Anna Di Nardo, Grazia Bottillo, Miriam Maiellaro, Emanuela Camera, Giorgia Cardinali, Charles Pilette, Marie Baeck, Peter Stärkel JAK/STAT Inhibition Normalizes Lipid Composition in 3D Human Epidermal Equivalents Challenged with Th2 Cytokines Cells 2024-04-29 [PMID: 38727296]

Bioinformatics

• Gene Symbol: ELOVL1