S1P3/EDG-3 Antibody (776808) [Phycoerythrin]

NS0 mouse myeloma cell line transfected with human S1P3/EDG-3 and eGFP was stained with either (A) Mouse Anti-Human S1P3/EDG-3 PE-conjugated Monoclonal Antibody (Catalog # FAB7524P) or (B) Mouse IgG2APhycoerythrin Isotype Control (Catalog # IC003P). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 776808
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

S1P3/EDG-3 Antibody (776808) [Phycoerythrin] Summary

• Immunogen: NS0 mouse myeloma cell line transfected with human S1P₃/EDG-3
  Accession # Q99500
• Specificity: Detects human S1P₃/EDG‑3 in direct ELISAs.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: S1PR3
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for S1P3/EDG-3 Antibody (776808) [Phycoerythrin]

• EDG3
• EDG-3
• EDG3FLJ37523
• Endothelial differentiation G-protein coupled receptor 3
• endothelial differentiation, sphingolipid G-protein-coupled receptor, 3
• FLJ93220
• G protein-coupled receptor, endothelial differentiation gene-3
• LPB3
• MGC71696
• S1P receptor 3
• S1P receptor EDG3
• S1P receptor Edg-3
• S1P3
• S1PR3
• sphingosine 1-phosphate receptor 3
• Sphingosine 1-phosphate receptor Edg-3
• sphingosine-1-phosphate receptor 3

Background

Sphingosine 1-Phosphate receptor-3 (S1P₃), also known as EDG-3, is a 378 amino acid (aa) seven-transmembrane receptor for the lysolipid phosphoric acid mediator, sphingosine 1-phosphate (S1P). S1P₃ interactions with S1P induce a range of responses including vasoconstriction, brachycardia, vascular endothelial and smooth muscle cell proliferation and migration, heart and liver fibrosis, and coagulation-induced inflammation. Extracellular portions of human S1P₃ show 74% aa identity with mouse and rat S1P₃.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: S1PR3
• Uniprot:
  • Q99500(Human)