ROR alpha/NR1F1 Antibody - BSA Free

Immunohistochemistry-Paraffin: ROR alpha/NR1F1 Antibody [NLS2337] - Human, Skin: Formalin-Fixed Paraffin-Embedded (FFPE)

Immunohistochemistry-Paraffin: ROR alpha/NR1F1 Antibody [NLS2337] - Human, Brain, Cortex: Formalin-Fixed Paraffin-Embedded (FFPE)

• Reactivity: Hu, Mu, Rt, Po, Bt, Bv, Ca, Eq, Ha, Pm, Pm, Rb, Ch, Fi, Ma-Op, Tr, Xp, Ze
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.81 mg/ml

ROR alpha/NR1F1 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 20 amino acid peptide from hinge domain of human ROR alpha/NR1F1.
• Epitope: Hinge domain
• Localization: Nuclear
• Specificity: Human ROR alpha/NR1F1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RORB (65%).
• Predicted Species: Fish (95%), Opossum (95%), Zebrafish (95%), Turkey (95%), Xenopus (95%), Chicken (95%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RORA
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin 11 - 17 ug/ml

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 0.81 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for ROR alpha/NR1F1 Antibody - BSA Free

• DKFZp686M2414
• MGC119326
• NR1F1
• NR1F1MGC119329
• nuclear receptor ROR-alpha
• Nuclear receptor RZR-alpha
• Nuclear receptor subfamily 1 group F member 1
• RAR-related orphan receptor A
• RAR-related orphan receptor alpha
• retinoic acid receptor-related orphan receptor alpha
• retinoid-related orphan receptor alpha
• Retinoid-related orphan receptor-alpha
• ROR alpha
• ROR1
• ROR2
• ROR3
• RORA
• RZRA
• RZR-ALPHA
• RZRAROR-alpha
• transcription factor RZR-alpha

Background

Retinoid-related orphan receptor alpha (ROR alpha), a NR1 Thyroid Hormone-Like Receptor, has been shown to affect the development of the central nervous system. Deletion of ROR alpha in mice causes severe impairment in the differentiation of cerebellar Purkinje neurons and results in the "staggerer" phenotype. ROR alpha has been suggested as a potential target in the treatment of chronic inflammatory diseases, including atherosclerosis and rheumatoid arthritis. Four isoforms that differ in the N-terminal regions have been isolated, and their spatiotemporal expression appears to be under isoform-specific regulation. ROR alpha isoforms have the same DNA-binding domain but display different DNA binding specificities. ROR alpha 1 binds to and constitutively activates transcription from a large subset of ROR elements, while ROR alpha 2 recognizes ROR elements with strict specificity and displays weaker transcriptional activity. The N-terminal domain and zinc-finger region work in concert to confer high affinity and specific DNA-binding properties to the ROR isoforms and suggest a novel strategy for the control of DNA-binding activities of nuclear receptors. It has been suggested that melatonin may affect ROR alpha transcriptional activity and expression of ROR alpha-regulated genes via modulation of the Ca(2+)/CaM signaling pathway. The structure of the ligand-binding domain (LBD) of ROR alpha and a potential natural ligand have been elucidated recently (Kallen et al. 2002) ROR alpha expression has been documented in human adipose, brain, breast, heart. liver, lung, muscle, ovary, PBLs, prostate, small intestine, spleen and testis. ESTs have been isolated from cancerous human tissues including lung, tongue, skeletal muscle, and germ cell, and from human normal tissues including liver/spleen, testis, brain, and skin.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RORA
• Entrez:
  • 6095(Human)