RIPK4 Antibody [Alexa Fluor® 647]

• Reactivity: Hu, Mu
• Applications: WB, IHC
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 647

RIPK4 Antibody [Alexa Fluor® 647] Summary

• Immunogen: E. coli-derived recombinant human/mouse RIPK4/RIP4
  Thr218-Thr450
  Accession # P57078
• Specificity: Detects human and mouse RIPK4/RIP4 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RIPK4 Antibody [Alexa Fluor® 647]

• ANKK2
• ANKRD3
• ANKRD3MGC129993
• ankyrin repeat domain 3
• Ankyrin repeat domain-containing protein 3
• DIKMGC129992
• EC 2.7.11
• EC 2.7.11.1
• PKC-delta-interacting protein kinase
• PKK
• receptor-interacting serine/threonine-protein kinase 4
• receptor-interacting serine-threonine kinase 4
• RIP4
• RIPK4
• serine/threonine-protein kinase ANKRD3

Background

Receptor-interacting serine-threonine kinase 4 (RIPK4/PKK) is a serine/threonine protein kinase which interacts with protein kinase C-delta, but also activates NFkappaB, and interacts with the Wnt3a coreceptor LRP6 after Wnt3a stimulation. RIPK4 is required for keratinocyte differentiation and has broad expression in epithelial tissues. Down regulation of RIPK4 has been observed in squamous cell carcinomas, hepatocellular carcinoma, urothelial carcinoma and cervical carcinoma. Mutations in in the RIPK4 gene cause Popliteal pterygium syndrome, lethal type (PPS-L), CHAND syndrome and Bartsocas-Papas syndrome.   

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.