RIG-I Antibody (2M6F10) [DyLight 405]

Product Discontinued

RIG-I Antibody (2M6F10) [DyLight 405] Summary

• Immunogen: A portion of amino acid 1-50 of human RIG-I was used as the immunogen. 31 PWFREEEVQYIQAEkNNkG 49
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: RIGI
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot

Reactivity Notes

Porcine reactivity reported in scientific literature (PMID: 27463126). The amino acid sequence used as immunogen is 100% homologous in human, chimp, orangutan and rhesus monkey, 85% homologous in pig, 79% homologous in mouse and horse and 73% homologous in rat.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for RIG-I Antibody (2M6F10) [DyLight 405]

• DDX58
• DEAD (Asp-Glu-Ala-Asp) box polypeptide 58
• DEAD box protein 58
• DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide
• DKFZp686N19181
• EC 3.6.4.13
• FLJ13599
• probable ATP-dependent RNA helicase DDX58
• retinoic acid inducible gene I
• Retinoic acid-inducible gene 1 protein
• Retinoic acid-inducible gene I protein
• RIG-1
• RIGI
• RIG-I
• RIG-IDKFZp434J1111
• RNA helicase RIG-I

Background

RIG-I, also known as DDX58, consists of a 106.6 kDa and a 101.4 kDa isoform and is involved in recognizing viruses and activating a response. Current research is being conducted with diseases and disorders such as hepatitis, rubella, influenza, rabies, hemorrhagic fever, lupus nephritis, and tick-borne encephalitis. The protein interacts in pathways such as NF-kappa signaling, cytosolic DNA-sensing, measles, influenza A, and mediated induction pathways with proteins such as CYLD, ZC3HAV1, DDX3X, MAVS, and WRNIP1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RIGI