Rheb Antibody


Western Blot: Rheb Antibody [NBP1-77214] - Western blot analysis of Rheb in mouse brain cell lysate with Rheb antibody at (A) 1, (B) 2, and (C) 4 ug/mL.
Immunohistochemistry-Paraffin: Rheb Antibody [NBP1-77214] - Mouse brain tissue with Rheb antibody at 2 ug/ml.
Immunofluorescence: Rheb Antibody [NBP1-77214] - Immunofluorescence of Rheb in Mouse Brain cells with Rheb antibody at 20 ug/mL.

Product Details

Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, IHC, IHC-P, IF
1 mg/ml

Order Details

Rheb Antibody Summary

Antibody was raised against a 15 amino acid peptide from the middle region of human Rheb.
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.02% Sodium Azide
1 mg/ml
Immunogen affinity purified


Application Notes
Rheb antibody can be used for the detection of Rheb by Western blot at 1 mg/ml.
Control Peptide
Rheb Peptide (NBP1-77214PEP)

Alternate Names for Rheb Antibody

  • GTP-binding protein Rheb
  • MGC111559
  • Ras homolog enriched in brainRHEB2Ras homolog enriched in brain 2
  • Rheb2


Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


Isotype Controls

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Blogs on Rheb.

TSC1 - a negative regulator of mTOR signaling
TSC1 is a tumor suppressor gene that encodes a 130 kDa protein called hamartin. TSC1 was first identified as an oncogenic driver of Tuberous Sclerosis, a condition characterized by numerous benign tumors of the skin, brain, heart, and lungs. A mut...  Read full blog post.

mTOR - a central regulator of cell metabolism
The mammalian target of rapamycin (mTOR) signaling pathway allows cells to monitor environmental signals like nutrient availability and oxygen levels. mTOR is a phosphoinositide 3-kinase (PI3K)-related protein that assembles into large protein comp...  Read full blog post.

Contact Information

Product PDFs


Gene Symbol RHEB

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