Rheb Products

Antibodies
Rheb Antibody (344912)
Rheb Antibody (344912)
MAB3426
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Mouse Monoclonal
Rheb Antibody (2C11)
Rheb Antibody (2C11)
H00006009-M01
Species: Hu, Mu, Rt
Applications: WB, ELISA
Host: Mouse Monoclonal
Rheb Antibody
Rheb Antibody
NBP1-77214
Species: Hu, Mu, Rt
Applications: WB, ELISA, IHC, IHC-P, IF
Host: Rabbit Polyclonal
Antibody Pairs
Rheb Antibody Pair
Rheb Antibody Pair
H00006009-PW1
Species: Hu
Applications: WB, IP
Lysates
Rheb Overexpression Lysate (D ...
Rheb Overexpression Lysate (Denatu...
H00006009-T01
Species: Hu
Applications: WB
Rheb Overexpression Lysate (N ...
Rheb Overexpression Lysate (Native)
NBP2-07725
Applications: WB
Proteins
Rheb Recombinant Protein
Rheb Recombinant Protein
NBC1-18435
Species: Hu
Applications: PAGE
Rheb Peptide
Rheb Peptide
NBP1-77214PEP
Species: Hu
Applications: AC
Rheb Peptide
Rheb Peptide
NBP1-76432PEP
Species: Hu
Applications: AC
RNAi
Rheb RNAi
Rheb RNAi
H00006009-R01
Species: Hu

Description

Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demon-strate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Product By Gene ID 6009
Alternate Names
  • GTP-binding protein Rheb
  • MGC111559
  • Ras homolog enriched in brainRHEB2Ras homolog enriched in brain 2

Research Areas for Rheb

Find related products by research area and learn more about each of the different research areas below.

Cancer
mTOR Pathway
Signal Transduction

Bioinformatics Tool for Rheb

Discover related pathways, diseases and genes to Rheb. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related Rheb Blog Posts

Check out the latest blog posts on Rheb.
TSC1 - a negative regulator of mTOR signaling
TSC1 is a tumor suppressor gene that encodes a 130 kDa protein called hamartin. TSC1 was first identified as an oncogenic driver of Tuberous Sclerosis, a condition characterized by numerous benign tumors of the skin, brain, heart, and lungs. A mut...    Read more.
mTOR - a central regulator of cell metabolism
The mammalian target of rapamycin (mTOR) signaling pathway allows cells to monitor environmental signals like nutrient availability and oxygen levels. mTOR is a phosphoinositide 3-kinase (PI3K)-related protein that assembles into large protein comp...    Read more.
Read more Rheb related blogs.