Rheb Antibody - BSA Free

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Western Blot: Rheb Antibody [NBP1-76432] - Rat heart cell lysate with Rheb antibody at (A) 2 and (B) 4 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, Rt, BvSpecies Glossary
Applications WB, ELISA
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
BSA Free
Concentration
1 mg/ml

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Catalog# & Formulation Size Price

Rheb Antibody - BSA Free Summary

Immunogen
Antibody was raised against a 14 amino acid synthetic peptide from the amino terminus of human Rheb. The immunogen is located within the first 50 amino acids of Rheb. Amino Acid Squence: PQSKSRKIAILGYR
Specificity
Post-translationally modified Rheb is sometimes observed at higher molecular weight.
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RHEB
Purity
Peptide affinity purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Western Blot 2-4 ug/ml
Application Notes
Rheb antibody can be used for the detection of Rheb by Western blot at 2 - 4 mg/ml. Post-translationally modified Rheb is sometimes observed at higher molecular weight.
Control Peptide
Rheb Peptide (NBP1-76432PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Peptide affinity purified

Alternate Names for Rheb Antibody - BSA Free

  • GTP-binding protein Rheb
  • MGC111559
  • Ras homolog enriched in brainRHEB2Ras homolog enriched in brain 2
  • Rheb
  • Rheb2

Background

Rheb (Ras homolog enriched in brain) is an evolutionarily conserved member of the Ras family of small GTP-binding proteins originally found to be rapidly induced by synaptic activity in the hippocampus following seizure. While it is expressed at relatively high levels in the brain, Rheb is widely expressed in other tissues and may be induced by growth factor stimulation. Similar to other family members, Rheb triggers activation of the Raf-MEK-MAPK pathway. Biochemical and genetic studies demonstrate that Rheb has an important role in regulating the insulin/Target of rapamycin (TOR) signaling pathway. TOR is a serine/threonine protein kinase that acts as a sensor for ATP and amino acids, balancing the availability of nutrients with protein translation and cell growth. A dimeric protein complex termed TSC1/TSC2 indirectly inhibits TOR activity by inhibiting Rheb via the GAP activity of TSC2.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Rheb Antibody (NBP1-76432)

Discover related pathways, diseases and genes to Rheb Antibody (NBP1-76432). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Research Areas for Rheb Antibody (NBP1-76432)

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Blogs on Rheb.

TSC1 - a negative regulator of mTOR signaling
TSC1 is a tumor suppressor gene that encodes a 130 kDa protein called hamartin. TSC1 was first identified as an oncogenic driver of Tuberous Sclerosis, a condition characterized by numerous benign tumors of the skin, brain, heart, and lungs. A mut...  Read full blog post.

mTOR - a central regulator of cell metabolism
The mammalian target of rapamycin (mTOR) signaling pathway allows cells to monitor environmental signals like nutrient availability and oxygen levels. mTOR is a phosphoinositide 3-kinase (PI3K)-related protein that assembles into large protein comp...  Read full blog post.

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Bioinformatics

Gene Symbol RHEB
Uniprot