Recombinant Rat CXCL3/CINC-2 beta Protein


There are currently no images for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity RtSpecies Glossary
Applications Bioactivity

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Recombinant Rat CXCL3/CINC-2 beta Protein Summary

Details of Functionality
Measured by its ability to induce myeloperoxidase release from cytochalasin B-treated human neutrophils. Schröder, J.M. et al. (1987) J. Immunol. 139:3474. The ED50 for this effect is 3-6 µg/mL. Measured by its ability to chemoattract BaF3 mouse pro‑B cells transfected with human CXCR2. The ED50 for this effect is 5-25 ng/mL.
E. coli-derived rat CXCL3/GRO gamma/CINC-2/DCIP-1 protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
7.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publication using
517-CB in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in Acetonitrile and TFA with BSA as a carrier protein.
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Rat CXCL3/CINC-2 beta Protein

  • chemokine (C-X-C motif) ligand 3
  • CINC-2
  • CINC-2b
  • C-X-C motif chemokine 3
  • CXCL3
  • Dcip1
  • Gm1960
  • GRO gamma
  • GRO3 oncogene
  • GRO3
  • GROG
  • GRO-gamma
  • GRO-gamma(1-73)
  • Growth-regulated protein gamma
  • Macrophage inflammatory protein 2-beta
  • melanoma growth stimulatory activity gamma
  • MGSA gamma
  • MIP2B
  • MIP-2b
  • MIP2-beta
  • SCYB3


The rat chemokines CINC (cytokine-induced neutrophil chemoattractant)-1, CINC-2 alpha, CINC-2 beta and CINC-3 (also named MIP-2) constitute a group of rat CXC chemokines that show significant sequence similarity to human GROs and mouse MIP-2 but not IL-8. CINC-2 alpha, CINC-2 beta were originally purified as novel neutrophil chemoattractants from the conditioned medium of rat granulation tissue which also contained CINC-1 and CINC-3. Based on amino acid (aa) sequence analysis of the purified CINC-2 alpha protein and sequencing of the CINC-2 beta cDNA clone, both mature CINC-2 alpha and CINC-2 beta were shown to contain 68 aa residues. The aa sequences of the two CINC-2 proteins are identical except for three carboxy-terminal residues. CINC-2 beta cDNA encodes a 100 aa residue precursor protein with a 32 aa residue signal peptide that is removed to yield the mature secreted protein. At the protein sequence level, mature CINC-2 proteins are 63% identical to CINC-1 and 80% identical to CINC-3. CINC-2 proteins represent the major chemokines purified from conditioned medium of granulation tissue or LPS-induced inflammatory exudate. Other cell types known to produce CINC-2 proteins include activated macrophages and fibroblasts.

Recombinant and natural CINC-2 proteins have been shown to be specific neutrophil chemoattractants both in vivo and in vitro. On the basis of cross-desensitization results of the various CINC proteins, it has been postulated that rat neutrophils have at least two classes of CINC receptors: a class of CINC-3-specific receptor as well as a second common receptor shared by all CINCs.

  1. Nakagawa, H. et al. (1994) Biochem. J. 301:545.
  2. Watanabe, K. et al. (1989) J. Biol. Chem. 264:19559.
  3. Haskill, S. et al. (1990) Proc. Natl. Acad. Sci. USA 87:7732.
  4. Shibata, F. et al. (1995) Eur. J. Biochem. 231:306.
  5. Al-Mokdad, M. et al. (1996) Biol. Pharm. Bull. 19:879.
  6. Murakami, K. et al. (1997) Biochem. and Biophys. Res. Commun. 232:562.
  7. Watanabe, K. et al. (1991) Exp. Mol. Pathol. 55:30.
  8. Nakagawa, H. et al. (1996) Biochem. and Biophys. Res. Commun. 220:945.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, CyTOF-ready, ELISA(Cap), ELISA(Det), ICC, ICFlow, Neut, ELISA(Sta)
Species: Hu
Species: Hu
Applications: WB, ELISA(Cap), ELISA(Det), Neut, ELISA(Sta)
Species: Hu
Applications: WB, Simple Western, ELISA(Cap), ELISA(Det), Neut, ELISA(Sta)
Species: Hu, Rb
Applications: WB, Flow, IHC-P
Species: Hu
Species: Rt
Applications: Bioactivity

Publications for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB)(1)

We have publications tested in 1 confirmed species: N/A.

We have publications tested in 1 application: ELISA development.

Filter By Application
ELISA development
All Applications
Filter By Species
All Species

Reviews for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB) (0)

There are no reviews for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional Array Products

Bioinformatics Tool for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB)

Discover related pathways, diseases and genes to CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB)

Discover more about diseases related to CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB).

Pathways for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB)

View related products by pathway.

PTMs for CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB)

Learn more about PTMs related to CXCL3/GRO gamma/CINC-2/DCIP-1 (517-CB).

Blogs on CXCL3/GRO gamma/CINC-2/DCIP-1

There are no specific blogs for CXCL3/GRO gamma/CINC-2/DCIP-1, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Rat CXCL3/CINC-2 beta Protein and receive a gift card or discount.


Gene Symbol Cxcl3