Recombinant Mouse Oncostatin M (OSM) Protein

• Reactivity: Mu
• Applications: Bioactivity

Recombinant Mouse Oncostatin M (OSM) Protein Summary

• Details of Functionality: Measured in a cell proliferation assay using NIH-3T3 mouse embryonic fibroblast cells. The ED 50 for this effect is 0.25-1 ng/mL.
• Source: E. coli-derived mouse Oncostatin M/OSM protein Ala24-Arg206, with an N-terminal Met
• Accession #: P53347.1
• N-terminal Sequence: Met
• Protein/Peptide Type: Recombinant Proteins
• Gene: Osm
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Endotoxin Note: <0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

• Dilutions:
  • Bioactivity
• Theoretical MW: 21 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  12 months from date of receipt, -20 to -70 degreesC as supplied. 1 month, 2 to 8 degreesC under sterile conditions after reconstitution. 3 months, -20 to -70 degreesC under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Purity: >97%, by SDS-PAGE under reducing conditions and visualized by silver stain
• Reconstitution Instructions: Reconstitute at 25 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Mouse Oncostatin M (OSM) Protein

• MGC20461
• oncostatin M
• oncostatin-M
• OSM

Background

Oncostatin M (OSM) is a member of a cytokine subfamily that includes IL-6, IL-11, LIF, CNTF, and cardiotrophin-1. These cytokines have overlapping biological functions and shared receptor components. Mouse OSM was cloned and identified as an immediate early gene induced in various myeloid and lymphoid cell lines by a subset of cytokines including IL-2, IL-3, GM-CSF and EPO. The mouse OSM cDNA encodes a 263 amino acid residue precursor protein that shows 48% identity with human OSM. Similar to human OSM, the C-terminal region of mouse OSM contains a highly charged region. Deletion of this C-terminal region appears to be essential for the formation of biologically active mOSM. The biological activity of human OSM has been shown to be mediated either by the LIF/OSM receptor complex composed of gp130 and LIF R alpha or by a human OSM specific receptor composed of gp130 and OSM R alpha . It remains to be determined if the biological activities of mouse OSM can also be mediated by both receptor complexes in mouse cells.

1. Yoshimura, A. et al. (1996) The EMBO Journal 15:1055.
2. Ray, P. et al. (1996) Endocrinology 137:1151.
3. Rose, T.M. and A.G. Bruce (1994) in Guidebook to Cytokines and Their Receptors, N.A. Nicola, editor, Oxford University Press, New York, p. 127.

Publications for Oncostatin M/OSM (495-MO)(73)

Publications using 495-MO

• Shang, X;Jia, J;Yu, J;Zou, S;Wang, Z;Xu, J;Li, H;Cao, B; Monocyte-derived macrophages support alveolar regeneration via oncostatin M post-H1N1 infection during the recovery phase Respiratory research 2025-10-08 [PMID: 41063200] (Bioassay, Mouse)
• Dai, Y;Aizenbud, L;Qin, K;Austin, M;Jaycox, JR;Cunningham, J;Wang, EY;Zhang, L;Fischer, S;Carroll, SM;van Aggelen, H;Kluger, Y;Herold, KC;Furchtgott, L;Kluger, HM;Ring, AM; Humoral determinants of checkpoint immunotherapy Nature 2025-07-23 [PMID: 40702172] (Bioassay, Human)
• Bréart, B;Williams, K;Krimm, S;Wong, T;Kayser, BD;Wang, L;Cheng, E;Cruz Tleugabulova, M;Bouziat, R;Lu, T;Yuen, K;Firmino, NS;Bravo, DD;Roels, J;Bhakta, A;Bevers, J;Lehoux, I;Gutierrez, A;Chestnut, Y;Klementowicz, JE;Arenzana, TL;Akhmetzyanova, I;Dixon, E;Chen, M;Tasneem, K;Yadav, R;Koeppen, H;Oh, SA;Delamarre, L;Huang, H;Lim, SA;Nakamura, G;Wang, J;Gao, C;Corpuz, R;Müller, S;West, NR; IL-27 elicits a cytotoxic CD8+ T cell program to enforce tumour control Nature 2025-02-05 [PMID: 39910298] (Bioassay, Mouse, Transgenic Mouse)
• Willis, A;Jeong, D;Liu, Y;Lithopoulos, MA;Yuzwa, SA;Frankland, PW;Kaplan, DR;Miller, FD; Single cell approaches define neural stem cell niches and identify microglial ligands that can enhance precursor-mediated oligodendrogenesis Cell reports 2025-01-15 [PMID: 39823226] (In vivo assay, Mouse)
• Zhou, Y;Stevis, PE;Cao, J;Ehrlich, G;Jones, J;Rafique, A;Sleeman, MW;Olson, WC;Franklin, MC; Structures of complete extracellular assemblies of type I and type II Oncostatin M receptor complexes Nature communications 2024-11-12 [PMID: 39532904] (Bioassay, Mouse)
• Strobl, K;Klufa, J;Jin, R;Artner-Gent, L;Krau beta , D;Novoszel, P;Strobl, J;Stary, G;Vujic, I;Griss, J;Holcmann, M;Farlik, M;Homey, B;Sibilia, M;Bauer, T; JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia EMBO molecular medicine 2024-11-09 [PMID: 39521937] (Ex Vivo, Transgenic Mouse)
• Wang, JC;Nikpoor, AR;Crosson, T;Kaufmann, E;Rafei, M;Talbot, S; BASOPHILS ACTIVATE PRURICEPTOR-LIKE VAGAL SENSORY NEURONS bioRxiv : the preprint server for biology 2024-06-11 [PMID: 38915548] (Bioassay, Mouse, Transgenic Mouse)
• Shrestha, H;Rädler, PD;Dennaoui, R;Wicker, MN;Rajbhandari, N;Sun, Y;Peck, AR;Vistisen, K;Triplett, AA;Beydoun, R;Sterneck, E;Saur, D;Rui, H;Wagner, KU; The Janus kinase 1 is critical for pancreatic cancer initiation and progression Cell reports 2024-05-10 [PMID: 38733583] (Bioassay, Mouse)
• Li, Y;Nie, Y;Yang, X;Liu, Y;Deng, X;Hayashi, Y;Plummer, R;Li, Q;Luo, N;Kasai, T;Okumura, T;Kamishibahara, Y;Komoto, T;Ohkuma, T;Okamoto, S;Isobe, Y;Yamaguchi, K;Furukawa, Y;Taniguchi, H; Integration of Kupffer cells into human iPSC-derived liver organoids for modeling liver dysfunction in sepsis Cell reports 2024-03-05 [PMID: 38451817] (Bioassay, Human)
• Bilgic, SN;Domaniku, A;Toledo, B;Agca, S;Weber, BZC;Arabaci, DH;Ozornek, Z;Lause, P;Thissen, JP;Loumaye, A;Kir, S; EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia Nature 2023-05-01 [PMID: 37165186] (Bioassay, Mouse)
• Haensel, D;Daniel, B;Gaddam, S;Pan, C;Fabo, T;Bjelajac, J;Jussila, AR;Gonzalez, F;Li, NY;Chen, Y;Hou, J;Patel, T;Aasi, S;Satpathy, AT;Oro, AE; Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche Nature communications 2023-05-10 [PMID: 37164949] (Cell Culture, Mouse)
• S Lee, R Karns, S Shin Mechanism of paracrine communications between hepatic progenitor cells and endothelial cells Cellular Signalling, 2022-08-30;100(0):110458. 2022-08-30 [PMID: 36055565] (Cell Culture, Mouse)
• JL Bailey, H Hang, A Boudreau, CM Elks Oncostatin M Induces Lipolysis and Suppresses Insulin Response in 3T3-L1 Adipocytes International Journal of Molecular Sciences, 2022-04-23;23(9):. 2022-04-23 [PMID: 35563078] (Bioassay, Mouse)
• M Valussi, J Besser, K Wystub-Lis, S Zukunft, M Richter, T Kubin, T Boettger, T Braun Repression of Osmr and Fgfr1 by miR-1/133a prevents cardiomyocyte dedifferentiation and cell cycle entry in the adult heart Science Advances, 2021-10-13;7(42):eabi6648. 2021-10-13 [PMID: 34644107] (Bioassay, Mouse)
• PP van Krieke, TS Odermatt, M Borsigova, M Blüher, S Wueest, D Konrad Oncostatin M suppresses browning of white adipocytes via gp130-STAT3 signaling Molecular Metabolism, 2021-09-20;0(0):101341. 2021-09-20 [PMID: 34547509] (Bioassay, Mouse)
• K Anzai, K Tsuruya, K Ida, T Kagawa, Y Inagaki, A Kamiya Kruppel-like factor 15 induces the development of mature hepatocyte-like cells from hepatoblasts Scientific Reports, 2021-09-17;11(1):18551. 2021-09-17 [PMID: 34535735] (Bioassay, Transgenic Mouse)
• N Tanimizu, N Ichinohe, Y Sasaki, T Itoh, R Sudo, T Yamaguchi, T Katsuda, T Ninomiya, T Tokino, T Ochiya, A Miyajima, T Mitaka Generation of functional liver organoids on combining hepatocytes and cholangiocytes with hepatobiliary connections ex vivo Nature Communications, 2021-06-07;12(1):3390. 2021-06-07 [PMID: 34099675] (Bioassay, Mouse)
• J Zeng, Y Jing, Q Wu, J Zeng, L Wei, J Liu Autophagy Is Required for Hepatic Differentiation of Hepatic Progenitor Cells via Wnt Signaling Pathway BioMed Research International, 2021-04-08;2021(0):6627506. 2021-04-08 [PMID: 33928152] (Bioassay, Rat)
• K Kwiecien, P Brzoza, M Bak, P Majewski, I Skulimowsk, K Bednarczyk, J Cichy, M Kwitniewsk The methylation status of the chemerin promoter region located from -?252 to +?258�bp regulates constitutive but not acute-phase cytokine-inducible chemerin expression levels Sci Rep, 2020-08-13;10(1):13702. 2020-08-13 [PMID: 32792625] (In Vivo, Bioassay, Mouse)
• S Alcalá, P Sancho, P Martinelli, D Navarro, C Pedrero, L Martín-Hij, S Valle, J Earl, M Rodríguez-, L Ruiz-Cañas, K Rojas, A Carrato, L García-Ber, MÁ Fernández-, PC Hermann, B Sainz ISG15 and ISGylation is required for pancreatic cancer stem cell mitophagy and metabolic plasticity Nat Commun, 2020-05-29;11(1):2682. 2020-05-29 [PMID: 32472071] (Bioassay, Mouse)
• J Lim, JH Choi, EM Park, YH Choi Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M Korean J. Physiol. Pharmacol., 2020-05-01;24(3):203-212. 2020-05-01 [PMID: 32395071] (Bioassay, Mouse)
• J Lim, JH Choi, EM Park, YH Choi Interaction of promyelocytic leukemia/p53 affects signal transducer and activator of transcription-3 activity in response to oncostatin M Korean J. Physiol. Pharmacol., 2020-05-01;24(3):203-212. 2020-05-01 [PMID: 32392911] (Bioassay, Mouse)
• M Oatley, ÖV Bölükbas?, V Svensson, M Shvartsman, K Ganter, K Zirngibl, PV Pavlovich, V Milchevska, V Foteva, KN Natarajan, B Baying, V Benes, KR Patil, SA Teichmann, C Lancrin Single-cell transcriptomics identifies CD44 as a marker and regulator of endothelial to haematopoietic transition Nat Commun, 2020-01-29;11(1):586. 2020-01-29 [PMID: 31996681] (Cell Culture, Mouse)
• S An, I Raju, B Surenkhuu, JE Kwon, S Gulati, M Karaman, A Pradeep, S Sinha, C Mun, S Jain Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies Ocul Surf, 2019-04-06;0(0):. 2019-04-06 [PMID: 30965123] (In Vivo, Mouse)
• M Simonneau, E Frouin, V Huguier, C Jermidi, JF Jégou, J Godet, A Barra, I Paris, P Levillain, S Cordier-Di, N Pedretti, FX Bernard, JC Lecron, F Morel, L Favot Oncostatin M is overexpressed in skin squamous-cell carcinoma and promotes tumor progression Oncotarget, 2018-11-23;9(92):36457-36473. 2018-11-23 [PMID: 30559930] (Bioassay, Mouse)
• J Martínez-F, A Prescott, S van Kaster, DL Pedrioli, I McLean, A Moles, T Reinheckel, V Poli, C Watts Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis Nat Commun, 2018-12-17;9(1):5343. 2018-12-17 [PMID: 30559339] (Bioassay, Mouse)
• D van Keulen, MG Pouwer, G Pasterkamp, AJ van Gool, MD Sollewijn, HMG Princen, D Tempel Inflammatory cytokine oncostatin M induces endothelial activation in macro- and microvascular endothelial cells and in APOE*3Leiden.CETP mice PLoS ONE, 2018-10-01;13(10):e0204911. 2018-10-01 [PMID: 30273401] (In Vivo, Mouse)
• T Yanagawa, H Sumiyoshi, K Higashi, S Nakao, R Higashiyam, H Fukumitsu, K Minakawa, Y Chiba, Y Suzuki, K Sumida, K Saito, A Kamiya, Y Inagaki Identification of a Novel Bone Marrow Cell-Derived Accelerator of Fibrotic Liver Regeneration Through Mobilization of Hepatic Progenitor Cells in Mice Stem Cells, 2018-10-31;37(1):89-101. 2018-10-31 [PMID: 30270488] (Bioassay, Mouse)
• Jacqueline M. Stephens, Jennifer L. Bailey, Hardy Hang, Victoria Rittell, Marilyn A. Dietrich, Randall L. Mynatt et al. Adipose Tissue Dysfunction Occurs Independently of Obesity in Adipocyte‐Specific Oncostatin Receptor Knockout Mice Obesity (Silver Spring) 2018-09-01 [PMID: 30226002] (In vivo assay, Mouse)
• K Tawara, C Bolin, J Koncinsky, S Kadaba, H Covert, C Sutherland, L Bond, J Kronz, JR Garbow, CL Jorcyk OSM potentiates preintravasation events, increases CTC counts, and promotes breast cancer metastasis to the lung Breast Cancer Res., 2018-06-14;20(1):53. 2018-06-14 [PMID: 29898744] (Bioassay, Mouse)
• SC Sampath, SC Sampath, ATV Ho, SY Corbel, JD Millstone, J Lamb, J Walker, B Kinzel, C Schmedt, HM Blau Induction of muscle stem cell quiescence by the secreted niche factor Oncostatin M Nat Commun, 2018-04-18;9(1):1531. 2018-04-18 [PMID: 29670077] (Bioassay, Mouse)
• T Machiyama, T So, Y Okuyama, S Kobayashi, HT Phung, A Asao, H Harigae, N Ishii TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation Biochem. Biophys. Res. Commun., 2018-04-02;0(0):. 2018-04-02 [PMID: 29596835] (Bioassay, Mouse)
• YY Sin, LL Ballantyne, CR Richmond, CD Funk Transplantation of Gene-Edited Hepatocyte-like Cells Modestly Improves Survival of Arginase-1-Deficient Mice Mol Ther Nucleic Acids, 2017-12-01;10(0):122-130. 2017-12-01 [PMID: 29499927] (Bioassay, Mouse)
• B Lloyd-Lewi, CC Krueger, TJ Sargeant, ME D'Angelo, MJ Deery, R Feret, JA Howard, KS Lilley, CJ Watson Stat3 mediated alterations in lysosomal membrane protein composition J. Biol. Chem., 2018-01-17;0(0):. 2018-01-17 [PMID: 29343516] (Bioassay, Mouse)
• F Torossian, B Guerton, A Anginot, KA Alexander, C Desterke, S Soave, HW Tseng, N Arouche, L Boutin, I Kulina, M Salga, B Jose, AR Pettit, D Clay, N Rochet, E Vlachos, G Genet, C Debaud, P Denormandi, F Genet, NA Sims, S Banzet, JP Levesque, JJ Lataillade, MC Le Bousse- Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications JCI Insight, 2017-11-02;2(21):. 2017-11-02 [PMID: 29093266] (Bioassay, Mouse)
• AJ Richard, H Hang, JM Stephens Pyruvate dehydrogenase complex (PDC) subunits moonlight as interaction partners of phosphorylated STAT5 in adipocytes and adipose tissue J. Biol. Chem., 2017-10-05;0(0):. 2017-10-05 [PMID: 28982698] (Bioassay, Mouse)
• X Jiang, JS Hawkins, J Lee, CO Lizama, FL Bos, JP Zape, P Ghatpande, Y Peng, J Louie, G Lagna, AC Zovein, A Hata Let-7 microRNA-dependent control of leukotriene signaling regulates the transition of hematopoietic niche in mice Nat Commun, 2017-07-25;8(1):128. 2017-07-25 [PMID: 28743859] (Bioassay, Mouse)
• M Yang, A Arai, N Udagawa, T Hiraga, Z Lijuan, S Ito, T Komori, T Moriishi, K Matsuo, K Shimoda, AH Zahalka, Y Kobayashi, N Takahashi, T Mizoguchi Osteogenic Factor Runx2 Marks a Subset of Leptin Receptor-Positive Cells that Sit Atop the Bone Marrow Stromal Cell Hierarchy Sci Rep, 2017-07-10;7(1):4928. 2017-07-10 [PMID: 28694469] (Bioassay, Mouse)
• YY Sin, PR Price, LL Ballantyne, CD Funk Proof-of-Concept Gene Editing for the Murine Model of Inducible Arginase-1 Deficiency Sci Rep, 2017-05-31;7(1):2585. 2017-05-31 [PMID: 28566761] (Bioassay, Mouse)
• XR Pan, YY Jing, WT Liu, ZP Han, R Li, Y Yang, JN Zhu, XY Li, PP Li, LX Wei Lipopolysaccharide induces the differentiation of hepatic progenitor cells into myofibroblasts via activation of the Hedgehog signalling pathway Cell Cycle, 2017-05-31;0(0):0. 2017-05-31 [PMID: 28562206] (Bioassay, Rat)
• V Kochat, Z Equbal, P Baligar, V Kumar, M Srivastava, A Mukhopadhy JMJD3 aids in reprogramming of bone marrow progenitor cells to hepatic phenotype through epigenetic activation of hepatic transcription factors PLoS ONE, 2017-03-22;12(3):e0173977. 2017-03-22 [PMID: 28328977] (Bioassay, Mouse)
• H Katayama, K Yasuchika, Y Miyauchi, H Kojima, R Yamaoka, T Kawai, E Yukie Yosh, S Ogiso, S Kita, K Yasuda, N Sasaki, K Fukumitsu, J Komori, T Ishii, S Uemoto Generation of non-viral, transgene-free hepatocyte like cells with piggyBac transposon Sci Rep, 2017-03-15;7(0):44498. 2017-03-15 [PMID: 28295042] (Bioassay, Mouse)
• N Tanimizu, N Ichinohe, M Yamamoto, H Akiyama, Y Nishikawa, T Mitaka Progressive induction of hepatocyte progenitor cells in chronically injured liver Sci Rep, 2017-01-04;7(0):39990. 2017-01-04 [PMID: 28051157] (Bioassay, Mouse)
• Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow Nat Cell Biol, 2016-09-19;18(10):1078-1089. 2016-09-19 [PMID: 27642788] (Bioassay, Mouse)
• Emma L Rawlins Lung epithelial tip progenitors integrate glucocorticoid- and STAT3-mediated signals to control progeny fate Development, 2016-08-30;143(20):3686-3699. 2016-08-30 [PMID: 27578791] (Bioassay, Mouse)
• Murine Oncostatin M acts via Leukemia Inhibitory Factor Receptor to phosphorylate STAT3 but not STAT1, an effect that protects bone mass J Biol Chem, 2016-08-18;0(0):. 2016-08-18 [PMID: 27539849] (Bioassay, Mouse)
• Liver Progenitors Isolated from Adult Healthy Mouse Liver Efficiently Differentiate to Functional Hepatocytes In Vitro and Repopulate Liver Tissue Stem Cells, 2016-07-13;0(0):. 2016-07-13 [PMID: 27375002] (Bioassay, Mouse)
• Kazuya Anzai Foetal hepatic progenitor cells assume a cholangiocytic cell phenotype during two-dimensional pre-culture Sci Rep, 2016-06-23;6(0):28283. 2016-06-23 [PMID: 27335264] (Bioassay, Mouse)
• Carrie M Elks Loss of oncostatin M signaling in adipocytes induces insulin resistance and adipose tissue inflammation in vivo J Biol Chem, 2016-06-20;0(0):. 2016-06-20 [PMID: 27325693] (Bioassay, Mouse)
• Takahiro Kodama Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma Proc Natl Acad Sci USA, 2016-05-31;113(24):E3384-93. 2016-05-31 [PMID: 27247392] (Bioassay, Mouse)
• LN Guthrie, K Abiraman, ES Plyler, NT Sprenkle, SA Gibson, BC McFarland, R Rajbhandar, AL Rowse, EN Benveniste, GP Meares Attenuation of PKR-like ER Kinase (PERK) Signaling Selectively Controls Endoplasmic Reticulum Stress-induced Inflammation Without Compromising Immunological Responses J. Biol. Chem., 2016-05-23;291(30):15830-40. 2016-05-23 [PMID: 27226638] (Bioassay, Mouse)
• Oncostatin M overexpression induces skin inflammation but is not required in the mouse model of imiquimod-induced psoriasis-like inflammation Eur J Immunol, 2016-05-12;0(0):. 2016-05-12 [PMID: 27122058] (Bioassay, Mouse)
• K Sakamoto, BL Wehde, KH Yoo, T Kim, N Rajbhandar, HY Shin, AA Triplett, PD Rädler, F Schuler, A Villunger, K Kang, L Hennighaus, KU Wagner Janus kinase 1 is essential for inflammatory cytokine signaling and mammary gland remodeling Mol Cell Biol, 2016-05-16;0(0):. 2016-05-16 [PMID: 27044867] (Bioassay, Mouse)
• Fagoonee S, Famulari E, Silengo L, Tolosano E, Altruda F Long Term Liver Engraftment of Functional Hepatocytes Obtained from Germline Cell-Derived Pluripotent Stem Cells. PLoS ONE, 2015-08-31;10(8):e0136762. 2015-08-31 [PMID: 26323094] (Bioassay, Mouse)
• Seto D, Kandarian S, Jackman R A Key Role for Leukemia Inhibitory Factor in C26 Cancer Cachexia. J Biol Chem, 2015-06-19;290(32):19976-86. 2015-06-19 [PMID: 26092726] (Bioassay, Mouse)
• Goyden J, Tawara K, Hedeen D, Willey J, Oxford J, Jorcyk C The Effect of OSM on MC3T3-E1 Osteoblastic Cells in Simulated Microgravity with Radiation. PLoS ONE, 2015-06-01;10(6):e0127230. 2015-06-01 [PMID: 26030441] (Bioassay, Mouse)
• Timothy J. Sargeant, Bethan Lloyd-Lewis, Henrike K. Resemann, Antonio Ramos-Montoya, Jeremy Skepper, Christine J. Watson Stat3 controls cell death during mammary gland involution by regulating uptake of milk fat globules and lysosomal membrane permeabilization Nature Cell Biology 2014-11-01 [PMID: 25283994] (Bioassay, Mouse)
• Meares G, Liu Y, Rajbhandari R, Qin H, Nozell S, Mobley J, Corbett J, Benveniste E PERK-dependent activation of JAK1 and STAT3 contributes to endoplasmic reticulum stress-induced inflammation. Mol Cell Biol, 2014-08-11;34(20):3911-25. 2014-08-11 [PMID: 25113558] (Bioassay, Mouse)
• Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M. PLoS ONE, 2014-07-10;9(7):e101937. 2014-07-10 [PMID: 25010647] (In Vivo, Mouse)
• Le Goff B, Singbrant S, Tonkin B, Martin T, Romas E, Sims N, Walsh N Oncostatin M acting via OSMR, augments the actions of IL-1 and TNF in synovial fibroblasts. Cytokine, 2014-04-22;68(2):101-9. 2014-04-22 [PMID: 24767864] (Bioassay, Mouse)
• Nobuhisa I, Osawa M, Uemura M, Kishikawa Y, Anani M, Harada K, Takagi H, Saito K, Kanai-Azuma M, Kanai Y, Iwama A, Taga T Sox17-mediated maintenance of fetal intra-aortic hematopoietic cell clusters. Mol Cell Biol, 2014-03-24;34(11):1976-90. 2014-03-24 [PMID: 24662049] (Bioassay, Mouse)
• Sun G, Dong L, An W Involvement of hepatic stimulator substance in the regulation of hepatoblast maturation into hepatocytes in vitro. Stem Cells Dev, 2014-05-02;23(14):1675-87. 2014-05-02 [PMID: 24640968] (Bioassay, Mouse)
• Yamamizu K, Piao Y, Sharov A, Zsiros V, Yu H, Nakazawa K, Schlessinger D, Ko M Identification of transcription factors for lineage-specific ESC differentiation. Stem Cell Reports, 2013-11-27;1(6):545-59. 2013-11-27 [PMID: 24371809] (Bioassay, Mouse)
• Komori T, Tanaka M, Senba E, Miyajima A, Morikawa Y Lack of oncostatin M receptor beta leads to adipose tissue inflammation and insulin resistance by switching macrophage phenotype. J Biol Chem, 2013-06-11;288(30):21861-75. 2013-06-11 [PMID: 23760275] (In Vivo, Mouse)
• Nicolaidou V, Wong MM, Redpath AN Monocytes Induce STAT3 Activation in Human Mesenchymal Stem Cells to Promote Osteoblast Formation. PLoS ONE, 2012-07-03;7(7):e39871. 2012-07-03 [PMID: 22802946] (Bioassay, Mouse)
• Morrison C, Mancini S, Cipollone J, Kappelhoff R, Roskelley C, Overall C Microarray and Proteomic Analysis of Breast Cancer Cell and Osteoblast Co-cultures: ROLE OF OSTEOBLAST MATRIX METALLOPROTEINASE (MMP)-13 IN BONE METASTASIS. J. Biol. Chem., 2011-07-22;286(39):34271-85. 2011-07-22 [PMID: 21784845] (Bioassay, Mouse)
• Roelandt P, Pauwelyn KA, Sancho-Bru P Human embryonic and rat adult stem cells with primitive endoderm-like phenotype can be fated to definitive endoderm, and finally hepatocyte-like cells. PLoS ONE, 2010-08-11;5(8):e12101. 2010-08-11 [PMID: 20711405] (Cell Culture, Rat)
• Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis. J. Immunol., 2010-03-24;184(0):5263-70. 2010-03-24 [PMID: 20335534] (In Vivo, Mouse)
• Jung ID, Noh KT, Lee CM, Chun SH, Jeong SK, Park JW, Park WS, Kim HW, Yun CH, Shin YK, Park YM Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem. Biophys. Res. Commun., 2010-03-04;394(2):272-8. 2010-03-04 [PMID: 20206608] (Bioassay, Mouse)
• Brounais B, David E, Chipoy C, Trichet V, Ferre V, Charrier C, Duplomb L, Berreur M, Redini F, Heymann D, Blanchard F Long term oncostatin M treatment induces an osteocyte-like differentiation on osteosarcoma and calvaria cells. Bone, 2009-01-03;44(5):830-9. 2009-01-03 [PMID: 19168167] (Western Blot)
• Sugaya M, Fang L, Cardones AR, Kakinuma T, Jaber SH, Blauvelt A, Hwang ST Oncostatin M enhances CCL21 expression by microvascular endothelial cells and increases the efficiency of dendritic cell trafficking to lymph nodes. J. Immunol., 2006-12-01;177(11):7665-72. 2006-12-01 [PMID: 17114436] (ELISA (Standard), In Vivo, Mouse)
• Gard AL, Gavin E, Solodushko V, Pennica D Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience, 2004-01-01;127(1):43-52. 2004-01-01 [PMID: 15219667] (Western Blot)
• Gyotoku E, Morita E, Kameyoshi Y, Hiragun T, Yamamoto S, Hide M The IL-6 family cytokines, interleukin-6, interleukin-11, oncostatin M, and leukemia inhibitory factor, enhance mast cell growth through fibroblast-dependent pathway in mice. Arch. Dermatol. Res., 2001-11-01;293(10):508-14. 2001-11-01 [PMID: 11820727] (Bioassay, Mouse)

Bioinformatics

• Gene Symbol: Osm
• Uniprot:
  • P53347.1()