Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF


There are currently no images for TROY/TNFRSF19 (1548-TR).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity HuSpecies Glossary
Applications Bioactivity

Order Details

Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF Summary

Details of Functionality
Measured by its binding ability in a functional ELISA. When Recombinant Human Lgr5/GPR49 Fc Chimera (Catalog # 8078-GP) is coated at 0.5 μg/mL, Recombinant Human TROY/TNFRSF19 Fc Chimera binds with an apparent Kd <500 nM.
Mouse myeloma cell line, NS0-derived human TROY/TNFRSF19 protein
Human TROY
Accession # AAF71828
N-terminus C-terminus
Accession #
N-terminal Sequence
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.


Theoretical MW
42 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
50-55 kDa, reducing conditions
Read Publication using
1548-TR in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS.
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF

  • TAJ
  • TAJ-alpha
  • TAJToxicity and JNK inducer
  • TNFRSF19
  • TROY
  • TROYtumor necrosis factor receptor superfamily member 19
  • tumor necrosis factor receptor superfamily, member 19


TROY (also known as TAJ and TNFRSF19) is a 45‑55 kDa member of the TNF receptor superfamily of molecules (1‑4). It is widely expressed in the embryo, but shows limited expression in adult. In particular, embryonic TROY is found in embryonic epithelium, neural tube, and mesenchyme, and developing neurons of the hippocampus and thalamus (5, 6). In the adult, TROY is found in the nervous system associated with dorsal root and retinal ganglia neurons, astrocytes, and microglia, and in hair follicles where it is expressed by dermal papilla matrix cells (4, 7, 8, 9). In human, TROY has also been found on melanoma cells, not normal melanocytes (10). TROY is reportedly a component of the Nogo-A receptor, taking the place of p75 in a membrane-bound LINGO-1:NgR1:TROY complex (6, 8, 9). This complex purportedly mediates axon repulsion initiated by one of five myelin-associated inhibitory factors (OMpg; CD100; Ephrin B3; Nogo-A; MAG) (6, 11). In the hair follicle, TROY binds LTa and acts with Eda to drive secondary hair follicle development (4, 12). Mature human TROY is a 394 amino acid (aa) type I transmembrane protein (1‑3). It possesses a 141 aa extracellular region (aa 30‑170) that contains three 40 aa TNFR cysteine motifs, and an extended 232 aa cytoplasmic domain (aa 192‑423). There is one potential isoform that shows a two aa substitution for aa 416‑423. The extracellular domains of human and mouse TROY share 90% aa identity.

  1. Hu, S. et al. (1999) Genomics 62:103.
  2. Eby, M.T. et al. (2000) J. Biol. Chem. 275:15336.
  3. Kojima, T. et al. (2000) J. Biol. Chem. 275:20742.
  4. Hashimoto, T. et al. (2008) Cell Cycle 7:106.
  5. Pispa, J. et al. (2003) Gene Exp. Patterns 3:675.
  6. Mi, S. (2008) Cytokine Growth Factor Rev. 19:245.
  7. Satoh, J. et al. (2007) Neuropathol. Appl. Neurobiol. 33:99.
  8. Shao, Z. et al. (2005) Neuron 45:353.
  9. Park, J.B. et al. (2000) Neuron 45:345.
  10. Spanjaard, R.A. et al. (2007) Int. J. Cancer 120:1304.
  11. Venkatesh, K. et al. (2007) J. Cell Biol. 177:393.
  12. Pispa, J. et al. (2008) Hum. Mol. Genet. 17:3380.

Customers Who Viewed This Item Also Viewed...

Species: Hu
Applications: WB, IHC
Species: Hu, Ca
Applications: WB, IHC, ICC
Species: Hu
Applications: Flow, IHC, CyTOF-ready, Neut
Species: Hu
Applications: WB, IP
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-Fr, IHC-P
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB
Species: Hu
Applications: WB, Flow, IHC, CyTOF-ready, Neut
Species: Hu
Applications: WB, IHC
Species: Hu, Mu, Rt
Species: Mu
Applications: WB, Block
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC/IF, IHC-P
Species: Hu, Mu, Rt
Applications: WB
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P

Publications for TROY/TNFRSF19 (1548-TR)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: Bioassay.

Filter By Application
All Applications
Filter By Species
All Species

Reviews for TROY/TNFRSF19 (1548-TR) (0)

There are no reviews for TROY/TNFRSF19 (1548-TR). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

FAQs for TROY/TNFRSF19 (1548-TR) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Additional Array Products

Bioinformatics Tool for TROY/TNFRSF19 (1548-TR)

Discover related pathways, diseases and genes to TROY/TNFRSF19 (1548-TR). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for TROY/TNFRSF19 (1548-TR)

Discover more about diseases related to TROY/TNFRSF19 (1548-TR).

Pathways for TROY/TNFRSF19 (1548-TR)

View related products by pathway.

PTMs for TROY/TNFRSF19 (1548-TR)

Learn more about PTMs related to TROY/TNFRSF19 (1548-TR).

Blogs on TROY/TNFRSF19

There are no specific blogs for TROY/TNFRSF19, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Nogo Antibody
KHSRP Antibody

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our Recombinant Human TROY/TNFRSF19 Fc Chimera Protein, CF and receive a gift card or discount.


Gene Symbol TNFRSF19