Recombinant Human TGF-beta RIII Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human TGF-beta RIII Protein Summary

Details of Functionality
Measured by its ability to inhibit TGF-beta 2 activity on HT‑2 mouse T cells. Tsang, M. et al. (1995) Cytokine 7:389. The ED50 for this effect is 20-50 ng/mL in the presence of 0.4 ng/mL of rhTGF-beta 2.
Source
Mouse myeloma cell line, NS0-derived human TGF-beta RIII protein
Gly21-Asp781
Accession #
N-terminal Sequence
Gly21
Protein/Peptide Type
Recombinant Proteins
Gene
TGFBR3
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Dilutions
  • Bioactivity
Theoretical MW
84 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
100-190 kDa, reducing conditions
Publications
Read Publications using
242-R3 in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity
>90%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human TGF-beta RIII Protein

  • betaglycan proteoglycan
  • Betaglycan
  • BGCAN
  • TBRIII
  • TGF-beta receptor type 3
  • TGF-beta receptor type III
  • TGF-beta RIII
  • TGFbetaRIII
  • TGFBR3
  • TGF-bRIII
  • TGFR-3
  • Transforming growth factor beta receptor III
  • transforming growth factor beta receptor type 3
  • transforming growth factor, beta receptor III (betaglycan, 300kDa)
  • transforming growth factor, beta receptor III

Background

Most cell types express three sizes of receptors for TGF-beta . These are designated Type I (53 kDa), Type II (70 - 85 kDa), and Type III (250 - 350 kDa). The Type I receptor is a membrane-bound serine/threonine kinase that apparently requires the presence of the Type II receptor to bind TGF-beta . The Type II receptor is also a membrane-bound serine/threonine kinase that binds TGF-beta 1 and TGF-beta 3 with high affinity and TGF-beta 2 with a much lower affinity. The Type I and Type II receptors together form a heterodimeric signaling complex that is essential for the transduction of the anti-proliferative signals of TGF-beta .

The Type III receptor is a transmembrane proteoglycan with a large extracellular domain and a 43 amino acid residue cytoplasmic domain. The cytoplasmic domain of the Type III receptor lacks an obvious signaling motif and the receptor may not be involved directly in signal transduction. The Type III receptor binds TGF-beta 2 with the highest affinity. Other TGF-beta isoforms also bind the Type III receptor, but with lower affinities. Cellular responsiveness to TGF-beta 2 appears to be dependent on the presence of the Type III receptor which can interact with the signaling receptor complex. In addition to the transmembrane Type III receptor, a soluble form of the receptor is secreted by some cell types. The physiological role of this soluble receptor remains to be determined. The recombinant TGF-beta soluble receptor Type III binds the TGF-beta isoforms differentially in solution and exhibits TGF-beta antagonistic activities in vitro.

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Publications for TGF-beta RIII (242-R3)(7)

We have publications tested in 2 confirmed species: Human, Rat.

We have publications tested in 2 applications: Bioassay, Preabsorption.


Filter By Application
Bioassay
(5)
Preabsorption
(1)
All Applications
Filter By Species
Human
(5)
Rat
(1)
All Species
Showing Publications 1 - 7 of 7.
Publications using 242-R3 Applications Species
AN Mwaura, MA Riaz, JB Maoga, E Mecha, COA Omwandho, G Scheiner-B, I Meinhold-H, L Konrad Role of Betaglycan in TGF-beta Signaling and Wound Healing in Human Endometriotic Epithelial Cells and in Endometriosis Biology, 2022;11(4):. 2022 [PMID: 35453712] (Bioassay, Human) Bioassay Human
OE Olsen, A Skjærvik, BF Størdal, A Sundan, T Holien TGF-? contamination of purified recombinant GDF15 PLoS ONE, 2017;12(11):e0187349. 2017 [PMID: 29161287] (Bioassay, Human) Bioassay Human
Olsen O, Wader K, Misund K, Vatsveen T, Ro T, Mylin A, Turesson I, Stordal B, Moen S, Standal T, Waage A, Sundan A, Holien T Bone morphogenetic protein-9 suppresses growth of myeloma cells by signaling through ALK2 but is inhibited by endoglin. Blood Cancer J, 2014;4(0):e196. 2014 [PMID: 24658374] (Bioassay, Human) Bioassay Human
Graham J, Chamberland A, Lin Q, Li X, Dai D, Zeng W, Ryan M, Rivera-Bermudez M, Flannery C, Yang Z Serine protease HTRA1 antagonizes transforming growth factor-beta signaling by cleaving its receptors and loss of HTRA1 in vivo enhances bone formation. PLoS ONE, 2013;8(9):e74094. 2013 [PMID: 24040176] (Bioassay, Human) Bioassay Human
Florio P, Ciarmela P, Reis FM, Toti P, Galleri L, Santopietro R, Tiso E, Tosi P, Petraglia F Inhibin alpha-subunit and the inhibin coreceptor betaglycan are downregulated in endometrial carcinoma. Eur. J. Endocrinol., 2005;152(2):277-84. 2005 [PMID: 15745937] (Preabsorption, Human) Preabsorption Human
Rosado E, 2019, Schwartz Z, Sylvia VL, Dean DD, Boyan BD Transforming growth factor-beta1 regulation of growth zone chondrocytes is mediated by multiple interacting pathways. 91, 2002;1590(1):1-15. 2002 [PMID: 12063164] (Bioassay, Rat) Bioassay Rat
Bandyopadhyay A, 2019, Zhu Y, Malik SN, Kreisberg J, Brattain MG, Sprague EA, Luo J, Lopez-Casillas F, Sun LZ Extracellular domain of TGFbeta type III receptor inhibits angiogenesis and tumor growth in human cancer cells. 101205, 2002;21(22):3541-51. 2002 [PMID: 12032856]

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Blogs on TGF-beta RIII.

TGF-beta RIII - a high affinity reservoir for TGF-beta I/II ligands with therapeutic potential
TGF beta (transforming growth factor beta) is a superfamily of cytokines that participate in a variety of cellular processes including growth, proliferation, differentiation, and apoptosis. There are 3 classes of receptors for TGF beta cytokines an...  Read full blog post.

TGF-beta RIII - A multi-functional regulator of the TGF-beta signaling pathway
Transforming growth factor-beta receptor III (TGF-beta RIII) is one of three receptors for the secreted growth factor TGF-beta. Unlike type I and type II TGF-beta receptors, TGF-beta RIII does not participate directly in the propagation of intracel...  Read full blog post.

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Bioinformatics

Gene Symbol TGFBR3
Uniprot