Recombinant Human Stabilin-2 (aa 2198-2295) Protein, CF

Images

 
There are currently no images for Stabilin-2 (3645-S2/CF).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Binding Activity
Format
Carrier-Free

Order Details

View Available Formulations
Catalog# & Formulation Size Price

Recombinant Human Stabilin-2 (aa 2198-2295) Protein, CF Summary

Details of Functionality
Measured by its ability to bind biotinylated Hyaluronan in a functional ELISA with an apparent KD for this binding is <0.1 nM.
Source
E. coli-derived human Stabilin-2 protein
MNHKVHM Human Stabilin
(Gly2198 - Val2295)
Accession # Q8WWQ8
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Met
Protein/Peptide Type
Recombinant Proteins
Gene
STAB2
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
12.6 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 100 μg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Stabilin-2 (aa 2198-2295) Protein, CF

  • CD44-like precursor FELL
  • DKFZP434E0321
  • FAS1 EGF-like and X-link domain containing adhesion molecule-2
  • FAS1 EGF-like and X-link domain-containing adhesion molecule 2
  • fasciclin egf-like, laminin-type egf-like, and link domain-containing scavengerreceptor-2
  • Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavengerreceptor 2
  • FEEL2
  • FEEL-2
  • FELE-2
  • FELL
  • FELL-2
  • FEX2
  • HARE
  • HAREFELL2
  • hepatic hyaluronan clearance receptor
  • Hyaluronan receptor for endocytosis
  • hyaluronic acid receptor for endocytosis
  • STAB2
  • STAB-2
  • stabilin 2
  • Stabilin2
  • Stabilin-2

Background

Stabilin-2, also known as HARE (hyaluronan receptor for endocytosis) and FEEL-2 (fasciclin, EGF-like, laminin type EGF-like, and link domain containing scavenger receptor 2), is a type I transmembrane multi-domain protein that is the closest homolog of stabilin-1 (1, 2). It is a scavenger receptor that is expressed on sinusoidal endothelial cells of liver, spleen, and lymph node (1, 2). Its 2439 amino acid (aa) extracellular domain contains seven fasciclin domains, multiple EGF-like and laminin type EGF-like domains, and a link domain related to molecules of the TSG-6 superfamily (3). The 72 aa cytoplasmic tail of Stabilin-2 contains a motif that allows the AP2 classical cargo adaptor to direct cargo into clathrin-coated pits (4). As a recycling receptor, stabilin-2 cycles from the membrane to clathrin-coated pits each 10 - 15 minutes, with about two thirds of the protein found within the endocytic system at any one time (4). The link domain binds and mediates the systemic clearance of hyaluronan (HA) (2 - 6). Within the link domain (aa 2198 - 2295), human stabilin-2 shares 86% and 89% aa identity with mouse and rat stabilin-2, respectively. Total human HA is about 15 grams, of which about 5 grams are cleared each day (5). Stabilin-2 also mediates the endocytosis of chondroitin and chondroitin sulfate, advanced glycosylation end-product (AGE), collagen N-terminal propeptides and acetylated LDL (4 - 7). Human stabilin-2 mRNA encodes a 2251 aa, 315 kDa protein that produces an isoform of 190 kDa through proteolytic cleavage (2, 6). The 190 kDa form lacks some N-terminal fasciclin and EGF-like domains, but shows similar activities when compared with the 315 kDa form (2, 6).

  1. Politz, O. et al. (2002) Biochem. J. 362:155.
  2. Zhou, B. et al. (2003) Glycobiology 13:339.
  3. Blundell, C.D. et al. (2005) J. Biol. Chem. 280:18189.
  4. Hansen, B. et al. (2005) Exp. Cell Res. 303:160.
  5. Harris, E.N. et al. (2004) J. Biol. Chem. 279:36201.
  6. Harris, E.N. et al. (2007) J. Biol. Chem. 282:2785.
  7. Tamura, Y. et al. (2003) J. Biol. Chem. 278:12613.

Customers Who Viewed This Item Also Viewed...

NBP1-33549
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-84444
Species: Hu
Applications: IHC, IHC-P
NBP1-47386
Species: Hu, Mu, Rb(-)
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-P, Flow-IC
H00009033-M01
Species: Hu, Rt
Applications: WB, ELISA
AF743
Species: Mu
Applications: WB, Flow, CyTOF-ready
NB600-41532
Species: Mu
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
NBP2-43648
Species: Hu, Mu, Rt, Ze
Applications: WB, ICC/IF, IHC, IHC-P
NBP2-50509
Species: Hu
Applications: WB, IHC, IP
NBP2-55298
Species: Hu
Applications: WB, IHC, IHC-P
NBP2-24916
Species: Hu, Mu, Rt, Bv
Applications: WB, IHC, IHC-P
NBP1-86616
Species: Hu
Applications: WB, IHC, IHC-P
NBP1-80917
Species: Hu
Applications: WB, IHC, IHC-P
NBP1-84553
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
AF2125
Species: Mu
Applications: WB, IHC
NBP1-85740
Species: Hu, Po
Applications: WB, ICC/IF, IHC, IHC-P
NBP1-81838
Species: Hu, Mu
Applications: WB, IHC, IHC-P
MAB4218
Species: Hu
Applications: WB, IHC

Publications for Stabilin-2 (3645-S2/CF) (0)

There are no publications for Stabilin-2 (3645-S2/CF).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for Stabilin-2 (3645-S2/CF) (0)

There are no reviews for Stabilin-2 (3645-S2/CF). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen

FAQs for Stabilin-2 (3645-S2/CF) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Other Available Formats

Additional Stabilin-2 Products

Bioinformatics Tool for Stabilin-2 (3645-S2/CF)

Discover related pathways, diseases and genes to Stabilin-2 (3645-S2/CF). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for Stabilin-2 (3645-S2/CF)

Discover more about diseases related to Stabilin-2 (3645-S2/CF).
 

Pathways for Stabilin-2 (3645-S2/CF)

View related products by pathway.

PTMs for Stabilin-2 (3645-S2/CF)

Learn more about PTMs related to Stabilin-2 (3645-S2/CF).

Blogs on Stabilin-2

There are no specific blogs for Stabilin-2, but you can read our latest blog posts.

Customers Who Bought This Also Bought

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our Recombinant Human Stabilin-2 (aa 2198-2295) Protein, CF and receive a gift card or discount.

Bioinformatics

Gene Symbol STAB2
Uniprot