Recombinant Human IL-11 Protein


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Recombinant Human IL-11 Protein Summary

Details of Functionality
Measured in a cell proliferation assay using T11 mouse plasmacytoma cells. Nordan, R.P. et al. (1987) J. Immunol. 139:813. The ED50 for this effect is 0.02-0.12 ng/mL.
The specific activity of recombinant human IL-11 is approximately 1.05 x 104 units/μg, which is calibrated against recombinant human IL-11 WHO International Standard (NIBSC code: 92/788).
Spodoptera frugiperda, Sf 21 (baculovirus)-derived human IL-11 protein
Accession #
N-terminal Sequence
Protein/Peptide Type
Recombinant Proteins
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.


Theoretical MW
19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
23 kDa, reducing conditions
Read Publications using
218-IL in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS and EDTA with BSA as a carrier protein.
>97%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
Reconstitution Instructions
Reconstitute at 50 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human IL-11 Protein

  • Adipogenesis inhibitory factor
  • AGIF
  • AGIFoprelvekin
  • IL11
  • IL-11
  • IL-11Oprelvekin
  • interleukin 11
  • interleukin-11
  • Oprelvekin


IL-11 (Interleukin 11) is a pleiotropic cytokine in the IL-6 family, which also includes LIF, CNTF, Oncostatin M, Cardiotrophin-1, IL-27 and IL-31 (1-3). In humans, IL-11 was also independently discovered as an adipogenesis inhibitory factor (AGIF) (3). The human IL-11 cDNA encodes a 199 amino acid (aa) precursor, which generates a 178 aa, 19 kDa mature unglycosylated protein. Mature human IL-11 shares 88%, 88%, and 96% aa sequence identity with mouse, rat and canine IL-11, respectively. IL-11 is secreted by osteoblasts, synoviocytes, fibroblasts, chondrocytes, intestinal myofibroblasts, and trophoblasts, among other cell types (1). It is found in the plasma mainly during inflammation, such as that associated with viral infection, cancer, or inflammatory arthritis, and is considered to be primarily anti‑inflammatory (1). It stimulates hematopoiesis and thrombopoiesis, regulates macrophage differentiation, and confers mucosal protection in the intestine (1). It has also been found to enhance T cell polarization toward Th2, promote B cell IgG production, increase osteoclast bone absorption, protect endothelial cells from oxidative stress, and regulate epithelial proliferation and apoptosis (1). IL-11 synergizes with several other cytokines to produce these effects, and its effects overlap with those of IL-6 (1). IL-11 receptor activation requires formation of a complex of two IL-11 molecules with two molecules of the ligand-binding IL-11 R alpha subunit and two molecules of the ubiquitously expressed cell signaling beta subunit, gp130 (4). A soluble form of IL-11 R alpha can bind IL-11 and either form a signaling complex with gp130 on the cell surface, or inhibit cell surface IL-11 R alpha /gp130 signaling (5-7).

  1. Putoczki, T. and M. Ernst (2010) J. Leukoc. Biol. 88:1109.
  2. Paul, S.R. et al. (1990) Proc. Natl. Acad. Sci. USA 87:7512.
  3. Kawashima, I. et al. (1991) FEBS Lett. 283:199.
  4. Barton, V.A. et al. (2000) J. Biol. Chem. 275:36197.
  5. Curtis, D.J. et al. (1997) Blood 90:4403.
  6. Baumann, H. et al. (1996) J. Immunol. 157:284.
  7. Karow, J. et al. (1996) Biochem. J. 318:489.

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Publications for IL-11 (218-IL)(20)

We have publications tested in 3 confirmed species: Human, Mouse, Primate - Macaca nemestrina (Southern Pig-tailed Macaque).

We have publications tested in 3 applications: Bioassay, Differentiation, In Vivo.

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Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
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Showing Publications 1 - 10 of 20. Show All 20 Publications.
Publications using 218-IL Applications Species
B Mair, J Tomic, SN Masud, P Tonge, A Weiss, M Usaj, AHY Tong, JJ Kwan, KR Brown, E Titus, M Atkins, KSK Chan, L Munsie, A Habsid, H Han, M Kennedy, B Cohen, G Keller, J Moffat Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies Cell Rep, 2019;27(2):599-615.e12. 2019 [PMID: 30970261] (Differentiation, Human) Differentiation Human
H Kim, D Kim, SA Choi, CR Kim, SK Oh, KE Pyo, J Kim, SH Lee, JB Yoon, Y Zhang, SH Baek KDM3A histone demethylase functions as an essential factor for activation of JAK2-STAT3 signaling pathway Proc. Natl. Acad. Sci. U.S.A., 2018;0(0):. 2018 [PMID: 30377265] (Bioassay, Human) Bioassay Human
VO Lewis, E Devarajan, M Cardó-Vila, DG Thomas, ES Kleinerman, S Marchiò, RL Sidman, R Pasqualini, W Arap BMTP-11 is active in preclinical models of human osteosarcoma and a candidate targeted drug for clinical translation Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):. 2017 [PMID: 28698375] (Bioassay, Human) Bioassay Human
Functional IL-33 receptors are expressed in early progenitor stages of allergy-related granulocytes Immunology, 2016;0(0):. 2016 [PMID: 27568595] (Bioassay, Human) Bioassay Human
Hong S, Choi J, Lee S, Park Y, Park K, Lee J, Kim J, Gajulapati V, Goo J, Singh S, Lee K, Kim Y, Im S, Ahn S, Rose-John S, Heo T, Choi Y A Novel Small-Molecule Inhibitor Targeting the IL-6 Receptor beta Subunit, Glycoprotein 130. J Immunol, 2015;195(1):237-45. 2015 [PMID: 26026064] (Bioassay, Human) Bioassay Human
Zhou C, Ji J, Cai Q, Shi M, Chen X, Yu Y, Zhu Z, Zhang J MTA2 enhances colony formation and tumor growth of gastric cancer cells through IL-11. BMC Cancer, 2015;15(0):343. 2015 [PMID: 25929737] (Bioassay, Human) Bioassay Human
Kwofie K, Scott M, Rodrigues R, Guerette J, Radford K, Nair P, Richards C Regulation of IL-17A responses in human airway smooth muscle cells by Oncostatin M. Respir Res, 2015;16(0):14. 2015 [PMID: 25849622] (Bioassay, Human) Bioassay Human
Simmons P, Robinson S, Munsell M, Thomas M, Javni J, Brouard N, Zweidler-McKay P, Shpall E Expression of a surface antigen (MA6) by peripheral blood CD34+ cells is correlated with improved platelet engraftment and may explain delayed platelet engraftment following cord blood transplantation. Stem Cells Dev, 2015;24(9):1066-72. 2015 [PMID: 25674667] (Bioassay, Human) Bioassay Human
Gori J, Butler J, Chan Y, Chandrasekaran D, Poulos M, Ginsberg M, Nolan D, Elemento O, Wood B, Adair J, Rafii S, Kiem H Vascular niche promotes hematopoietic multipotent progenitor formation from pluripotent stem cells. J Clin Invest, 2015;125(3):1243-54. 2015 [PMID: 25664855] (Bioassay, Primate - Macaca nemestrina (Southern Pig-tailed Macaque)) Bioassay Primate - Macaca nemestrina (Southern Pig-tailed Macaque)
Boettcher S, Gerosa R, Radpour R, Bauer J, Ampenberger F, Heikenwalder M, Kopf M, Manz M Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood, 2014;124(9):1393-403. 2014 [PMID: 24990886] (Bioassay, Mouse) Bioassay Mouse
Show All 20 Publications.

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Gene Symbol IL11