Recombinant Human Cardiotrophin-1 (CT-1) Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity
Format
Carrier-Free

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Recombinant Human Cardiotrophin-1 (CT-1) Protein, CF Summary

Details of Functionality
Measured in a cell proliferation assay using TF‑1 human erythroleukemic cells. Kitamura, T. et al. (1989) J. Cell Physiol. 140:323. The ED50 for this effect is 0.25‑1.25 ng/mL.
Source
E. coli-derived human Cardiotrophin-1/CT-1 protein
Ser2-Ala201
Accession #
N-terminal Sequence
Ser2
Protein/Peptide Type
Recombinant Proteins
Gene
CTF1
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
21 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using
612-CD/CF in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.
Buffer
Supplied as a 0.2 μm filtered solution in Acetonitrile and TFA.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Cardiotrophin-1 (CT-1) Protein, CF

  • cardiophin 1
  • cardiotrophin 1
  • Cardiotrophin1
  • Cardiotrophin-1
  • CT-1CT1
  • CTF1

Background

Cardiotrophin-1 (CT-1) is a member of the cytokine family which also includes IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), and ciliary neurotrophic factor (CNTF). It was originally isolated based on its ability to induce cardiac myocyte hypertrophy in vitro. CT-1 has since been shown to be a pleiotrophic cytokine with overlapping actions with other IL-6 family members on a variety of cell types. Human CT-1 encodes a 201 amino acid (aa) residue protein that lacks a hydrophobic signal peptide. The mechanism of CT-1 release from cells is currently not understood. Human and mouse CT-1 share 80% aa sequence identity and exhibit cross-species activity. CT-1 is highly expressed in heart, skeletal muscle, liver, lung and kidney. Lower levels of CT-1 expression is also seen in testis and brain. CT-1 initiates downstream signaling pathways through the heterodimerization of gp130 and the LIF receptor beta subunit. A third  alpha receptor subunit has been implicated in the receptor complex.

  1. Pennica, D. et al. (1996) Cytokine and Growth Factor Reviews 7:81.
  2. Robledo, O. et al. (1997) J. Biol. Chem. 272:4855.

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Publications for Cardiotrophin-1/CT-1 (612-CD/CF)(7)

We have publications tested in 3 confirmed species: Human, Rat, N/A.

We have publications tested in 2 applications: Bioassay, WB Ctrl.


Filter By Application
Bioassay
(6)
WB Ctrl
(1)
All Applications
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Human
(5)
Rat
(1)
N/A
(1)
All Species
Showing Publications 1 - 7 of 7.
Publications using 612-CD/CF Applications Species
E Martínez-M, J Ibarrola, A Fernández-, E Santamaria, J Fernández-, P Rossignol, F Jaisser, N López-Andr Differential Proteomics Identifies Reticulocalbin-3 as a Novel Negative Mediator of Collagen Production in Human Cardiac Fibroblasts Sci Rep, 2017;7(1):12192. 2017 [PMID: 28939891] (Bioassay, Human) Bioassay Human
Emdad L, D'Souza SL, Kothari HP, Qadeer ZA, Germano IM Efficient differentiation of human embryonic and induced pluripotent stem cells into functional astrocytes. Stem Cells Dev., 2012;21(3):404-10. 2012 [PMID: 21631388] (Bioassay, Human) Bioassay Human
Larsen JV, Hansen M, Moller B, Madsen P, Scheller J, Nielsen M, Petersen CM Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer. Mol. Cell. Biol., 2010;17(0):4175. 2010 [PMID: 20584990] (Bioassay, Human) Bioassay Human
Duluc D, Corvaisier M, Blanchard S, Catala L, Descamps P, Gamelin E, Ponsoda S, Delneste Y, Hebbar M, Jeannin P Interferon-gamma reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages. Int. J. Cancer, 2009;125(2):367-73. 2009 [PMID: 19378341] (Bioassay, Human) Bioassay Human
Fritzenwanger M, Meusel K, Foerster M, Kuethe F, Krack A, Figulla HR Cardiotrophin-1 induces interleukin-6 synthesis in human monocytes. Cytokine, 2007;38(3):137-44. 2007 [PMID: 17637508] (Bioassay, Human) Bioassay Human
Gard AL, Gavin E, Solodushko V, Pennica D Cardiotrophin-1 in choroid plexus and the cerebrospinal fluid circulatory system. Neuroscience, 2004;127(1):43-52. 2004 [PMID: 15219667] (WB Ctrl, N/A) WB Ctrl N/A
Freed DH, Borowiec AM, Angelovska T Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways. Cardiovasc. Res., 2003;60(2):365-75. 2003 [PMID: 14613866] (Bioassay, Rat) Bioassay Rat

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Bioinformatics

Gene Symbol CTF1
Entrez
Uniprot