Recombinant Human Annexin A13 Protein, CF

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Product Details

Summary
Reactivity HuSpecies Glossary
Format
Carrier-Free

Order Details

Recombinant Human Annexin A13 Protein, CF Summary

Details of Functionality
Bioassay data are not available.
Source
E. coli-derived human Annexin A13 protein
Gly2-His316 (Arg86His), with a C-terminal 6-His tag
Accession #
N-terminal Sequence
Gly2
Protein/Peptide Type
Innovator Recombinant Proteins
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Endotoxin Note
<0.10 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
36 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
35 kDa, reducing conditions

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution Instructions
Reconstitute at 250 μg/mL in PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Annexin A13 Protein, CF

  • Annexin A13
  • Annexin XIII
  • Annexin-13
  • ANX13
  • ANX13annexin, intestine-specific
  • ANXA13
  • Intestine-specific annexin
  • ISA
  • ISAannexin-13
  • MGC150460

Background

Human Annexin A13 (ANXA13), also known as Annexin XIII or Annexin 13, is a 35 kDa member of the Annexin family (1), which are calcium-dependent phospholipid-binding proteins being preferentially located on the cytosolic face of the plasma membrane. The Annexins consist of a unique N-terminal domain followed by a homologous C-terminal core domain containing the phospholipid-binding sites. The C-terminal domain of Annexin A13 is comprised of four 60‑70 aa annexin repeats which form a tightly packed disc known as the Annexin domain. Alternate splicing generates an additional isoform with a 41 amino acid (aa) deletion near the N‑terminus (2). Members of the Annexin family play a role in cytoskeletal interactions, phospholipase inhibition, regulation of cellular growth, and intracellular signal transduction pathways (3, 4). Human Annexin A13 shares approximately 86% and 91% aa sequence identity with mouse and dog Annexin A13 respectively.
  1. Wice, B. et al. (1992) J Cell Biol. 116:405.
  2. Turnay, J. et al. (2005) Biochem. J. 389:899.
  3. Gerke, V. et al. (2002) Physiol. Rev. 82:331.
  4. Gerke, V. et al. (2005) Nat. Rev. Mol. Cell Biol. 6:449.

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