Recombinant Human Activin RIIB Fc Chimera (NS0-expressed)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Bioactivity

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Recombinant Human Activin RIIB Fc Chimera (NS0-expressed) Summary

Details of Functionality
Measured by its ability to inhibit Activin A-induced hemoglobin expression in K562 human chronic myelogenous leukemia cells. Schwall, R.H. et al. (1991) Method Enzymol. 198:340. Approximately 0.3-1 µg/mL of rhActivin RIIB/Fc Chimera will inhibit 50% of the biological response due to 3 ng/mL of rhActivin A.
Source
Mouse myeloma cell line, NS0-derived human Activin RIIB protein
Met Human Activin RIIB
(Ser19 - Thr 134)
Accession # CAA54671
IEGRMD Human IgG1
(Pro100 - Lys330)
6-His tag
N-terminus C-terminus
Accession #
N-terminal Sequence
Met
Structure / Form
Disulfide-linked homodimer
Protein/Peptide Type
Recombinant Proteins
Gene
ACVR2B
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Note
<0.01 EU per 1 μg of the protein by the LAL method.

Applications/Dilutions

Theoretical MW
41 kDa (monomer).
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
SDS-PAGE
60 kDa, reducing conditions
Publications
Read Publications using
339-RB in the following applications:

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Purity
>95%, by SDS-PAGE under reducing conditions and visualized by silver stain
Reconstitution Instructions
Reconstitute at 200 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Recombinant Human Activin RIIB Fc Chimera (NS0-expressed)

  • activin A receptor, type IIB
  • Activin receptor type IIB
  • activin receptor type-2B
  • Activin RIIB
  • ActivinRIIB
  • ACTRIIB
  • ActR-IIB
  • ACVR2B
  • EC 2.7.11
  • EC 2.7.11.30
  • MGC116908

Background

Activin isoforms and other members of the TGF-beta  superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Seven type I and five type II receptors, including the two type I and the two type II activin receptors, designated ActR-I(A), ActR-IB, ActR-II(A) and ActR-IIB, have been cloned from mammals. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated, adding to the complexity of the activin receptor system. Different activin isoforms bind with different high-affinities to the various type II isoforms. Type I activin receptors do not bind directly to activin, but will associate with the type II receptor-activin complex and initiate signal transduction. Besides the activin isoforms, ActR-II will also bind inhibin, BMP-2 and BMP-7 with lower affinities. ActR-I can also bind and form signaling complexes with the BMP-2/7-bound BMPR-II. Activin type II receptors are highly conserved. Human, mouse and rat type II activin receptors share greater than 98% amino acid sequence homology. Recombinant soluble activin type II receptors bind activin with high affinity, and are potent activin antagonists.

  1. Attisano, L. et al. (1996) Mol. and Cell Biol. 16:1066.
  2. Woodruff, T.K. (1998) Biochem. Pharmacology 55:953.

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339-RB
Species: Hu
Applications: Bioactivity

Publications for Activin RIIB (339-RB)(4)

We have publications tested in 3 confirmed species: Human, Mouse, Bacteria - Staphylococcus aureus.

We have publications tested in 2 applications: Bioassay, ELISA (Detection).


Filter By Application
Bioassay
(3)
ELISA (Detection)
(1)
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Human
(2)
Mouse
(1)
Bacteria - Staphylococcus aureus
(1)
All Species

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Bioinformatics

Gene Symbol ACVR2B
Uniprot