RCAN1 Antibody

Product Discontinued

RCAN1 Antibody Summary

• Immunogen: Synthetic peptide EEVDLQDLPSAT-C, representing the N-Terminus of the human protein according to NP_004405.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: RCAN1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA 1:100-1:2000
  • Western Blot 1:100-1:2000
• Application Notes: Peptide ELISA: antibody detection limit dilution 1:8000. Western Blot: Preliminary experiments gave no signal but low background in human heart and kidney extracts at up to 1ug/ml. We would appreciate any feedback from people in the field - have any results been reported with other antibodies/lysates?

Reactivity Notes

Cross reacts with Human. Expected from sequence similarity: Mouse, Rat, Dog and Cow.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris (pH 7.3), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for RCAN1 Antibody

• ADAPT78
• calcipressin-1
• calcium and oxidant-inducible mRNA
• Down syndrome candidate region 1
• Down syndrome critical region gene 1
• Down syndrome critical region protein 1
• DSC1
• modulatory calcineurin-interacting protein 1
• Myocyte-enriched calcineurin-interacting protein 1
• near DSCR proline-rich protein
• regulator of calcineurin 1CSP1DSCR1MCIP1RCN1

Background

RCAN1 interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. RCAN1 is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for RCAN1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RCAN1
• Entrez:
  • 1827(Human)
• Uniprot:
  • NP_004405.(Human)