RCAN1 Antibody (1B1)

Product Discontinued

RCAN1 Antibody (1B1) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: DSCR1 (AAH02864, 1 a.a. - 100 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MEEVDLQDLPSATIACHLDPRVFVDGLCRAKFESLFRTYDKDITFQYFKSFKRVRINFSNPFSAADARLQLHKTEFLGKEMKLYFAQTLHIGSSHLAPPN
• Specificity: DSCR1 (1B1)
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: RCAN1
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for RCAN1 Antibody (1B1)

• ADAPT78
• calcipressin-1
• calcium and oxidant-inducible mRNA
• Down syndrome candidate region 1
• Down syndrome critical region gene 1
• Down syndrome critical region protein 1
• DSC1
• modulatory calcineurin-interacting protein 1
• Myocyte-enriched calcineurin-interacting protein 1
• near DSCR proline-rich protein
• regulator of calcineurin 1CSP1DSCR1MCIP1RCN1

Background

The protein encoded by this gene interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Chronic overexpression of this gene may lead to neurofibrillary tangles such as those associated with Alzheimer disease. Three transcript variants encoding three different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for RCAN1 Antibody (H00001827-M03)(1)

Publication using H00001827-M03

• Xing L, Salas M, Zhang H et al. Creation and characterization of BAC-transgenic mice with physiological overexpression of epitope-tagged RCAN1 (DSCR1). Mamm Genome. 2012-10-25 [PMID: 23096997]

Bioinformatics

• Gene Symbol: RCAN1
• Entrez:
  • 1827(Human)
• OMIM:
  • 602917(Human)
• Uniprot:
  • AAH02864(Human)