RbAp46 Antibody

Images

 
Western Blot: RbAp46 Antibody [NB120-3535] - Analysis of RbAp46 on 1) Du-145 2) LNCaP and 3) Hep-G2 cell extracts.
Immunocytochemistry/ Immunofluorescence: RbAp46 Antibody [NB120-3535] - Immunolocalization of RbAp46 in HeLa cells.
Western Blot: RbAp46 Antibody [NB120-3535] - Figure 1: IF of RbAp46 in HeLa cells. Figure 2: WB of RbAp46 on 1) Du-145 2) LNCaP and 3) Hep-G2 cell extracts.

Product Details

Summary
Reactivity Hu, Mu, FiSpecies Glossary
Applications WB, ICC/IF, IHC
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

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Catalog# & Conjugate Size Price

RbAp46 Antibody Summary

Immunogen
Synthetic peptide corresponding to residues M(1) A S K E M F E D T V E E(13) C of human RbAp46.
Localization
Nuclear.
Specificity
NB120-3535 detects retinoblastoma protein (Rb) associated protein 46 (RbAp46) from human cells.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
RBBP7
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5 ug/ml
  • Immunocytochemistry/Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1.0 ug/ml
Theoretical MW
46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Publications
Read Publications using NB120-3535.

Reactivity Notes

Expected cross-reactivity with Rat (100%), Xenopus Laevis (92%), and Chicken (84%) base on sequence homology. Mouse reactivity reported in scientific literature (PMID: 14645126).

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS containing 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for RbAp46 Antibody

  • G1/S transition control protein-binding protein RbAp46
  • Histone acetyltransferase type B subunit 2
  • histone-binding protein RBBP7
  • MGC138867
  • Nucleosome-remodeling factor subunit RBAP46
  • RbAp46
  • RBBP-7
  • retinoblastoma binding protein 7
  • Retinoblastoma-binding protein 7MGC138868
  • Retinoblastoma-binding protein p46
  • retinoblastoma-binding protein RbAp46

Background

Retinoblastoma protein (Rb) associated protein 46 (RbAp 46) is a nuclear protein that has been shown to interact directly with retinoblastoma protein and is a component of the mSin3 corepressor complex as are the histone deacetylase proteins (HDACs). RbAp 46 shares about 75% sequence identity with the closely related RbAp 48, and appears to be functionally related to the yeast MSI 1 protein in that overexpression of RbAp 46 suppresses heat shock sensitivity in a RAS pathway dependent manner. RbAp 46 has also been demonstrated to be up-regulated by the Wilms' tumor suppressor gene product, WT1. Additionally, cells transfected with RbAp46 have shown strong inhibition of growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for RbAp46 Antibody (NB120-3535)(3)

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol RBBP7