Rat/Mouse Cytochrome c Quantikine ELISA Kit



Product Details

Reactivity Mu, RtSpecies Glossary
Applications ELISA

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Rat/Mouse Cytochrome c Quantikine ELISA Kit Summary

The Quantikine Rat/Mouse Cytochrome c Immunoassay is a 2.5 hour solid phase ELISA designed to measure rat and mouse cytochrome c. It contains natural rat cytochrome c and antibodies raised against cytochrome c, and because of the 100% sequence identity of rat and mouse cytochrome c, this kit can be used to accurately quantitate natural rat or mouse cytochrome c in cell lysates and subcellular fractions.
This kit recognizes both the reduced and oxidized forms of natural rat and mouse cytochrome c.
Assay Type
Solid Phase Sandwich ELISA
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using MCTC0.

Packaging, Storage & Formulations

Store the unopened product at 2 - 8 °C. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Rat/Mouse Cytochrome c Quantikine ELISA Kit

  • CYCS
  • Cytochrome c
  • cytochrome c, somatic
  • THC4


Cytochrome c is a small, highly conserved, heme-containing protein involved in mitochondrial electron transport. Cytochrome c is released from the mitochondria in response to pro-apoptotic stimuli and serves as a cofactor in initiating the activation of the APAF-1/Caspase-9 complex. The effect of specific proteins and/or small molecules on the initiation of the intrinsic apoptotic pathway can be evaluated in an in vitro system of isolated mitochondria by monitoring the release of cytochrome c.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Cytochrome c (MCTC0)(31)

We have publications tested in 3 confirmed species: Human, Mouse, Rat.

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Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using MCTC0 Applications Species
YH Cheah, CY Liu, BS Yip, CL Wu, KL Peng, JW Cheng Strategy to Enhance Anticancer Activity and Induced Immunogenic Cell Death of Antimicrobial Peptides by Using Non-Nature Amino Acid Substitutions Biomedicines, 2022;10(5):. 2022 [PMID: 35625834] (Human) Human
CH Tsai, CT Pan, YY Chang, SY Peng, PC Lee, CW Liao, CT Shun, PT Li, VC Wu, CH Chou, IJ Tsai, CS Hung, YH Lin Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo Biomedicines, 2021;9(8):. 2021 [PMID: 34440149] (Rat) Rat
NB Bloch, TE Wales, MS Prew, HR Levy, JR Engen, LD Walensky The conformational stability of pro-apoptotic BAX is dictated by discrete residues of the protein core Nature Communications, 2021;12(1):4932. 2021 [PMID: 34389733] (Mouse) Mouse
W Lin, X Qian, LK Yang, J Zhu, D Wang, CH Hang, Y Wang, T Chen Inhibition of miR-134-5p protects against kainic acid-induced excitotoxicity through Sirt3-mediated preservation of mitochondrial function Epilepsy research, 2021;176(0):106722. 2021 [PMID: 34273723] (Mouse) Mouse
AZ Spitz, E Zacharioud, DE Reyna, TP Garner, E Gavathioti Eltrombopag directly inhibits BAX and prevents cell death Nature Communications, 2021;12(1):1134. 2021 [PMID: 33602934] (Mouse) Mouse
E Jangholi, ZN Sharifi, M Hoseinian, MR Zarrindast, HR Rahimi, A Mowla, H Aryan, MA Javidi, Y Parsa, F Ghaffarpas, S Yadollah-D, HZ Arani, F Shahi, S Movassaghi Verapamil Inhibits Mitochondria-Induced Reactive Oxygen Species and Dependent Apoptosis Pathways in Cerebral Transient Global Ischemia/Reperfusion Oxid Med Cell Longev, 2020;2020(0):5872645. 2020 [PMID: 33133347] (Rat) Rat
MY Farrugia, M Caruana, S Ghio, A Camilleri, C Farrugia, RJ Cauchi, S Cappelli, F Chiti, N Vassallo Toxic oligomers of the amyloidogenic HypF-N protein form pores in mitochondrial membranes Sci Rep, 2020;10(1):17733. 2020 [PMID: 33082392] (Human) Human
DT Cohen, TE Wales, MW McHenry, JR Engen, LD Walensky Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX Cell Rep, 2020;30(10):3229-3239.e6. 2020 [PMID: 32160532] (Mouse) Mouse
IJ Tsai, WC Lin, YH Yang, YL Tseng, YH Lin, CH Chou, YK Tsau High Concentration of C5a-Induced Mitochondria-Dependent Apoptosis in Murine Kidney Endothelial Cells Int J Mol Sci, 2019;20(18):. 2019 [PMID: 31510052] (Mouse) Mouse
P Naserzadeh, G Taghizadeh, B Atabaki, E Seydi, J Pourahmad A Comparison of Mitochondrial Toxicity of Mephedrone on three Separate Parts of Brain including Hippocampus, Cortex and Cerebellum Neurotoxicology, 2019;0(0):. 2019 [PMID: 30802467] (Rat) Rat
Show All 31 Publications.

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Blogs on Cytochrome c.

Pathway Highlight: Three key factors that contribute to cellular heterogeneity in apoptosis
Have you ever wondered why cells in the same population respond differently to an apoptotic stimulus? Apoptosis, a form of programmed cell death, is vital for the removal of unwanted or damaged cells. As with most cellular processes, too much or to...  Read full blog post.

The use of apoptosis antibodies and controls in cell death research
Apoptosis is a method of programmed cell death that is notably characterized by a morphological change in cellular nuclei and membrane appearance.  Not to be confused with necrosis, apoptosis is a pathway that is induced by a variety of factors tha...  Read full blog post.

Bcl-2 - an antiapoptotic protein with an important role in cancer cell survival
B-cell lymphoma 2 (Bcl-2) protein is an oncogene that normally acts as an apoptotic inhibitor and localizes to the mitochondrial membrane where it prevents the release of cytochrome c. The Bcl-2 protein family consists of over 20 proteins each co...  Read full blog post.

Cytochrome C - a mediator of apoptosis
Cytochrome C is a small heme protein within the inner mitochondrial membrane responsible for carrying electrons within the respiratory transport chain.  Additionally, cytochrome c has also been identified as a player in programmed cell death (apop...  Read full blog post.

Cytochrome C in Apoptosis, Immune Response and Cancer
Cytochrome C is an electron carrier protein that localizes in mitochondrion intermembrane space and has been identified as one of the key signaling molecules of apoptosis or programmed cell death. Suppression of the anti-apoptotic members or activatio...  Read full blog post.

Mitofilin and the Mitochondrial Inner Membrane Organizing System (MINOS)
Mitofilin was originally described as a heart muscle protein due to its high expression in the heart. Recently, analysis of the human heart mitochondrial proteome demonstrated that Mitofilin is one of the most abundant mitochondrial proteins (1). Rese...  Read full blog post.

Bax Research Gives New Insight into Oxidative Apoptosis
Bax is a member of the Bcl-2 family; an extensive range of proteins which play key roles in apoptosis, or programmed cell death, by regulating outer mitochondrial membrane permeability. We at Novus Biologicals are one of the leading antibody suppliers...  Read full blog post.

The Role of the Caspase 3 Antibody in Apoptosis Research
The caspases are a group of cysteine protease enzymes essential to apoptosis, inflammation and necrosis. Caspase 3 has been identified as one of the key mediators of apoptosis.Human caspases form three distinct groups: cytokine activators, which are...  Read full blog post.

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