RANK/TNFRSF11A Antibody Pair

Product Discontinued

RANK/TNFRSF11A Antibody Pair Summary

• Description: Quality control test: Standard curve using mammalian expressed recombinant protein as an analyte. This antibody pair set comes with matched antibody pair to detect and quantify protein level of human TNFRSF11A.
  
  
• Capture antibody: mouse monoclonal anti-TNFRSF11A (100 ug)
• Detection antibody: biotinylated mouse monoclonal anti-TNFRSF11A IgG1 Kappa (50 ug)
• Standard Curve Range: 1 ng/ml to 100 ng/ml
• Assay Type: Sandwich ELISA
• Clonality: Monoclonal
• Gene: TNFRSF11A
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Sandwich ELISA 1 ng/ml - 100 ng/ml

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: Immunogen affinity purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for RANK/TNFRSF11A Antibody Pair

• CD265 antigen
• CD265
• FEO
• loss of heterozygosity, 18, chromosomal region 1
• ODFR
• ODFROSTS
• OFE
• OPTB7
• Osteoclast differentiation factor receptor
• PDB2
• RANK
• RANKLOH18CR1
• Receptor activator of NF-KB
• receptor activator of nuclear factor-kappa B
• TNFRSF11A
• TRANCE R
• TRANCER
• tumor necrosis factor receptor superfamily member 11A
• tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
• tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Background

Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNFR1 and Fas. Receptor activator of NF-kB (RANK) is a recently cloned member of the TNFR superfamily with no significant homology to other members of this family (1). RANK ligand (RANKL/TRANCE/ OPGL) (mAbs to RANKL is also available from Imgenex, Cat # IMG-133) binds to RANK on dendritic cells, upregulates the expression of anti-apoptotic protein BcL-XL suggesting a role in dendritic cell survival (2). The cytoplasmic domain of RANK interacts with TRAF2, TRAF5 and TRAF6 (3,4). Overexpression of RANK activates NF-kB and c-Jun-terminal kinase (JNK) pathways (3). Recent studies have shown that RANK interaction with TRAF6 activates NF-kB, whereas JNK activation is mediated through binding of RANK to TRAF2 (4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Pairs are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: TNFRSF11A