RANK/TNFRSF11A Antibody (Hu200) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: ELISA
• Clone: Hu200
• Clonality: Monoclonal
• Host: Human
• Conjugate: Alexa Fluor 594

RANK/TNFRSF11A Antibody (Hu200) [Alexa Fluor® 594] Summary

• Additional Information: Recombinant Monoclonal Antibody For Research Use Only
• Immunogen: Mouse myeloma cell line NS0-derived recombinant human RANK/TNFRSF11A
  extracellular domain
  Accession # Q9Y6Q6
• Specificity: Detects human RANK/TNFRSF11A in ELISA.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Human
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for RANK/TNFRSF11A Antibody (Hu200) [Alexa Fluor® 594]

• CD265 antigen
• CD265
• FEO
• loss of heterozygosity, 18, chromosomal region 1
• ODFR
• ODFROSTS
• OFE
• OPTB7
• Osteoclast differentiation factor receptor
• PDB2
• RANK
• RANKLOH18CR1
• Receptor activator of NF-KB
• receptor activator of nuclear factor-kappa B
• TNFRSF11A
• TRANCE R
• TRANCER
• tumor necrosis factor receptor superfamily member 11A
• tumor necrosis factor receptor superfamily, member 11a, activator of NFKB
• tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Background

RANK (receptor activator of NF-kappa B, also known as TRANCE receptor, osteoclast differentiation factor receptor [ODFR]) and TNFRSF11A is a member of the tumor necrosis factor receptor family. The full length human RANK cDNA encodes a type I transmembrane protein of 616 amino acids with a predicted 184 amino acid extracellular domain and a 383 amino acid cytoplasmic domain. The extracellular domain contains two potential N-linked glycosylation sites. RANK shares significant amino acid homology with other members of the TNF R family in its extracellular four cysteine-rich repeats. Human and murine RANK share 81% amino acid identity in their extracellular domains. RANK is widely expressed with highest levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. RANK is expressed in dendritic cells. In activated human peripheral blood T lymphocytes, RANK expression is induced by IL-4 and TGF-beta . Multiple tumor necrosis factor receptor-associated factors (TRAFs) are involved in the signaling of RANK. TRANCE (TNF-related activation-induced cytokines, also known as RANK ligand [RANKL], osteoprotegerin ligand [OPGL], and osteoclast differentiation factor [ODF]) is the ligand for RANK. The biological functions mediated through RANK include activation of NF-kappa B and c-jun N-terminal kinase, enhancement of T cell growth and dendritic cell function, induction of osteoclastogenesis, and lymph node organogenesis. Soluble RANK is able to block TRANCE induced biological activity. Bio-Techne's Denosumab biosimilar is produced using the full-length amino acid sequence which is identical to that of the original therapeutic antibody.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • Q9Y6Q6()