RAGEF2 Antibody

Western Blot: RAGEF2 Antibody [NBP1-06550] - Whole cell lysate from HeLa cells. PDZ-GEF2 was also immunoprecipitated by rabbit anti-PDZ-GEF2 antibody NBP1-06550.

• Reactivity: Hu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Concentration: 0.2 mg/ml

RAGEF2 Antibody Summary

• Description: Novus Biologicals Rabbit RAGEF2 Antibody (NBP1-06550) is a polyclonal antibody validated for use in WB and IP. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: The immunogen recognized by this antibody maps to a region between residue 625 and 675 of human PDZ domain containing guanine nucleotide exchange factor (GEF) 2 using the numbering given in entry NP_057424.2 (GeneID 51735).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: RAPGEF6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation 1:10-1:500
  • Western Blot 1:100-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: TBS and 0.1% BSA
• Preservative: 0.09% Sodium Azide
• Concentration: 0.2 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for RAGEF2 Antibody

• DKFZp667N084
• DKFZp686I15116
• KIA001LB
• PDZ domain-containing guanine nucleotide exchange factor 2
• PDZ domain-containing guanine nucleotide exchange factor I
• PDZ-GEF2RA-GEF-2PDZGEF2PDZ domain containing guanine nucleotide exchange factor (GEF) 2
• RAGEF2
• Rap guanine nucleotide exchange factor (GEF) 6
• rap guanine nucleotide exchange factor 6

Background

PDZ-GEF2 is a guanine nucleotide exchange factor (GEF) for Rap GTPases. It contains one PDZ-signaling domain, a Ras-association (RA) domain, and a region related to a cyclic nucleotide binding domain (RCBD). PDZ-GEF1 functions to catalyze the exchange of GDP for GTP and activate Rap1A, Rap1B, and Rap2B GTPase activity. PDZ-GEF2 has been shown to activate Rap1A and Rap1B to promote the maturation of cell-cell adherens junctions. Alternative names for PDZ-GEF2 include Rap guanine nucleotide exchange factor 6, PDZ domain-containing guanine nucleotide exchange factor 2, RAPGEF6, RA-GEF-2, RAGEF2, PDZGEF2, and KIA001LB.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RAPGEF6
• Entrez:
  • 51735(Human)
• Uniprot:
  • NP_057424.2(Human)