R-Spondin 1 Antibody [DyLight 405]

• Reactivity: Hu
• Applications: B/N
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: DyLight 405

R-Spondin 1 Antibody [DyLight 405] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived human R-Spondin 1
  Arg31-Ala263
  Accession # Q2MKA7
• Specificity: Detects human R-Spondin 1 in direct ELISAs. In direct ELISAs, approximately 6% cross-reactivity with recombinant mouse R-Spondin 1 is observed and less than 1% cross-reactivity with recombinant human (rh) R-Spondin 2, rhR-Spondin 3, and rhR-Spondin 4 is observed.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: RSPO1
• Purity: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Neutralization
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for R-Spondin 1 Antibody [DyLight 405]

• Cristin 3
• CRISTIN3
• FLJ40906Roof plate-specific spondin-1
• HRspo1
• roof plate-specific spondin
• RSPO
• RSPO1
• RSpondin 1
• R-Spondin 1
• R-spondin homolog (Xenopus laevis)
• RSPONDIN
• R-spondin1
• R-spondin-1

Background

R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: RSPO1