R-Spondin 1 Products

Antibodies
R-Spondin 1 Antibody
R-Spondin 1 Antibody
AF3474
Species: Mu
Applications: WB, IHC
Host: Goat Polyclonal
R-Spondin 1 Antibody
R-Spondin 1 Antibody
NBP1-77354
Species: Hu, Mu, Rt
Applications: WB, ELISA, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
R-Spondin 1 Antibody (422407) ...
R-Spondin 1 Antibody (422407)
MAB4658
Species: Hu, Mu
Applications: WB
Host: Mouse Monoclonal
Lysates
R-Spondin 1 Overexpression Ly ...
R-Spondin 1 Overexpression Lysate ...
NBP2-08561
Applications: WB
Proteins
Recombinant Human R-Spondin 1 ...
Recombinant Human R-Spondin 1 Protein
4645-RS
Species: Hu
Applications: BA
Recombinant Mouse R-Spondin 1 ...
Recombinant Mouse R-Spondin 1 (CHO...
7150-RS
Species: Mu
Applications: BA
Recombinant Human R-Spondin 1 ...
Recombinant Human R-Spondin 1 Biot...
BT4645
Species: Hu
Applications: BA
Conjugate Catalog # Availability Size Price
RNAi
R-Spondin 1 RNAi
R-Spondin 1 RNAi
H00284654-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 284654
Alternate Names
  • roof plate-specific spondin
  • RSPO
  • CRISTIN3
  • R-spondin1
  • RSPONDIN
  • R-spondin-1
  • hRspo1
  • FLJ40906Roof plate-specific spondin-1
  • R-spondin homolog (Xenopus laevis)

PTMs for R-Spondin 1

Learn more about PTMs related to R-Spondin 1.

Phosphorylation
Methylation
Cleavage

Bioinformatics Tool for R-Spondin 1

Discover related pathways, diseases and genes to R-Spondin 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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