PTTG1 Antibody

Western Blot: Securin Antibody [H00009232-B02P] - Analysis of PTTG1 expression in transfected 293T cell line by PTTG1 polyclonal antibody. Lane 1: PTTG1 transfected lysate(22.00 KDa). Lane 2: Non-transfected lysate.

Immunocytochemistry/Immunofluorescence: Securin Antibody [H00009232-B02P] - Analysis of purified antibody to PTTG1 on HeLa cell. (antibody concentration 10 ug/ml)

Product Discontinued

PTTG1 Antibody Summary

• Immunogen: PTTG1 (NP_004210.1, 1 a.a. - 202 a.a.) full-length human protein. MATLIYVDKENGEPGTRVVAKDGLKLGSGPSIKALDGRSQVSTPRFGKTFDAPPALPKATRKALGTVNRATEKSVKTKGPLKQKQPSFSAKKMTEKTVKAKSSVPASDDAYPEIEKFFPFNPLDFESFDLPEEHQIAHLPLSGVPLMILDEERELEKLFQLGPPSPVKMPSPPWESNLLQSPSSILSTLDVELPPVCCDIDI
• Specificity: This product is specific for Human PTTG1 purified MaxPab mouse polyclonal antibody (B02P) [Gene ID: 9232].
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: PTTG1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Mouse polyclonal antibody raised against a full-length human PTTG1 protein.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for PTTG1 Antibody

• EAP1MGC126883
• ESP1-associated protein 1
• Esp1-associated protein
• hPTTG
• pituitary tumor-transforming 1
• Pituitary tumor-transforming gene 1 protein
• PTTGMGC138276
• securin
• Tumor-transforming protein 1
• TUTR1HPTTG

Background

The product of the oncogene PTTG, pituitary tumor transforming gene, is a human homolog of the anaphase-inhibitor vertebrate protein, securin. PTTG is a 22 kDa protein that contains a basic amino-terminal domain and an acidic carboxy-terminal domain, which acts as a transactivation domain when fused to a heterologous DNA binding domain. Human PTTG is overexpressed in Jurkat and is also detected in human thymus, testis, and placenta. PTTG is mainly expressed in the cytoplasm and is also partially localized to the nucleus. Vertebrate PTTG regulates the separin Esp1, which promotes chromatid separation, to overcome the cohesive forces that hold sister chromatids together. This regulatory function of PTTG suggests that defective regulation of cohesion may contribute to cancer by promoting chromosome instability. Although vertebrate PTTG shares cell-cycle functions with its yeast securin counterparts Pds1p and Cut2, none share sequence homology.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTTG1
• Uniprot:
  • NP_004210.1(Human)