PTTG1 Products

Description

The encoded protein is a homolog of yeast securin proteins, which prevent separins from promoting sister chromatid separation. It is an anaphase-promoting complex (APC) substrate that associates with a separin until activation of the APC. The gene product has transforming activity in vitro and tumorigenic activity in vivo, and the gene is highly expressed in various tumors. The gene product contains 2 PXXP motifs, which are required for its transforming and tumorigenic activities, as well as for its stimulation of basic fibroblast growth factor expression. It also contains a destruction box (D box) that is required for its degradation by the APC. The acidic C-terminal region of the encoded protein can act as a transactivation domain. The gene product is mainly a cytosolic protein, although it partially localizes in the nucleus.

Bioinformatics

Entrez	9232 Human
Uniprot	NP_004210 Human
Product By Gene ID	9232
Alternate Names	EAP1MGC126883 ESP1-associated protein 1 Esp1-associated protein hPTTG pituitary tumor-transforming 1 Pituitary tumor-transforming gene 1 protein PTTGMGC138276 securin Tumor-transforming protein 1 TUTR1HPTTG

Research Areas for PTTG1

Find related products by research area and learn more about each of the different research areas below.

Breast Cancer
Cell Cycle and Replication
Mitotic Regulators