PTPRB Antibody

Product Discontinued

PTPRB Antibody Summary

• Immunogen: Peptide with sequence C-ENHSFSQERTVPDK corresponding to internal region according to NP_001103224.1, NP_002828.3.
• Epitope: ENHSFSQERTVPDK - internal region
• Specificity: This antibody is expected to recognize both reported isoforms (NP_001103224.1; NP_002828.3).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: PTPRB
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:16000
• Application Notes: WB: Preliminary experiments in human, mouse and rat testis lysates gave no specific signal but low background.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Notes

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Alternate Names for PTPRB Antibody

• DKFZp686E2262
• DKFZp686H15164
• EC 3.1.3.48
• FLJ44133
• HPTPB
• HPTP-BETA
• MGC142023
• MGC59935
• protein tyrosine phosphatase, receptor type, B
• protein tyrosine phosphatase, receptor type, beta polypeptide
• Protein-tyrosine phosphatase beta
• PTPB
• receptor-type tyrosine-protein phosphatase beta
• R-PTP-BETA
• Vascular endothelial protein tyrosine phosphatase
• VEPTP
• VE-PTP

Background

PTPRB is a member of the protein tyrosine phosphatase (PTP) family. The family comprises at least 37 proteins, characterized by a catalytic phosphatase domain of approximately 240 amino acids, and includes both transmembrane and cytosolic enzymes. PTP1B is a transmembrane PTP. The PTPs have high substrate specificity for phosphotyrosyl proteins, at the primary sequence level sharing little similarity with the protein serine phosphatases, protein threonine phosphatases, or the acid and alkaline phosphatases. PTP beta interacts with and regulates the tyrosine phosphorylation level of catenins, which are critical in physiological and pathological events such as cell migration, adhesion and transformation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRB
• Entrez:
  • 5787(Human)
  • 314843(Rat)
• Uniprot:
  • NP_001103224.1(Human)