PTP pi/PTPRU Antibody (PTPRU/7616) [Alexa Fluor™ Plus 680]

• Reactivity: Hu
• Applications: IHC
• Clone: PTPRU/7616
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 680

PTP pi/PTPRU Antibody (PTPRU/7616) [Alexa Fluor™ Plus 680] Summary

• Immunogen: Recombinant fragment (around aa1-200) of human PTP pi/PTPRU protein (exact sequence is proprietary)
• Localization: Cell junction. Cell membrane. Single-pass type I membrane protein.
• Isotype: IgG2 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PTPRU
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for PTP pi/PTPRU Antibody (PTPRU/7616) [Alexa Fluor™ Plus 680]

• FMI
• GLEPP1
• hPTP-J
• pancreatic carcinoma phosphatase 2
• PCP2
• PCP-2
• pi R-PTP-Psi
• protein tyrosine phosphatase J
• protein tyrosine phosphatase, receptor type, U
• protein-tyrosine phosphatase J
• protein-tyrosine phosphatase pi
• PTP pi
• PTP
• PTP-J
• PTP-PI
• PTPPSI
• PTPRO
• PTP-RO
• PTPRU
• Receptor protein tyrosine phosphatase hPTP-J
• R-PTP-PSI
• R-PTP-U

Background

The protein encoded by the PTPRU gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Three alternatively spliced transcript variants, which encode distinct proteins, have been reported. (provided by RefSeq)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: PTPRU